A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

Janet L. Lathey, Jan M. Agosti, Jay Nelson, Lawrence Corey, Susan A. Gregory, James H. Morrissey, Thomas S. Edgington, Michael B A Oldstone

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalClinical Immunology and Immunopathology
Volume54
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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Thromboplastin
Monocytes
Acquired Immunodeficiency Syndrome
Messenger RNA
Interleukin-1
Tumor Necrosis Factor-alpha
AIDS-Related Complex
Fibrin
Coinfection
Thrombin
Lipopolysaccharides
Disease Progression
Peptide Hydrolases
HIV

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Lathey, J. L., Agosti, J. M., Nelson, J., Corey, L., Gregory, S. A., Morrissey, J. H., ... Oldstone, M. B. A. (1990). A selective defect in tissue factor mRNA expression in monocytes from AIDS patients. Clinical Immunology and Immunopathology, 54(1), 1-13. https://doi.org/10.1016/0090-1229(90)90001-7

A selective defect in tissue factor mRNA expression in monocytes from AIDS patients. / Lathey, Janet L.; Agosti, Jan M.; Nelson, Jay; Corey, Lawrence; Gregory, Susan A.; Morrissey, James H.; Edgington, Thomas S.; Oldstone, Michael B A.

In: Clinical Immunology and Immunopathology, Vol. 54, No. 1, 1990, p. 1-13.

Research output: Contribution to journalArticle

Lathey, JL, Agosti, JM, Nelson, J, Corey, L, Gregory, SA, Morrissey, JH, Edgington, TS & Oldstone, MBA 1990, 'A selective defect in tissue factor mRNA expression in monocytes from AIDS patients', Clinical Immunology and Immunopathology, vol. 54, no. 1, pp. 1-13. https://doi.org/10.1016/0090-1229(90)90001-7
Lathey, Janet L. ; Agosti, Jan M. ; Nelson, Jay ; Corey, Lawrence ; Gregory, Susan A. ; Morrissey, James H. ; Edgington, Thomas S. ; Oldstone, Michael B A. / A selective defect in tissue factor mRNA expression in monocytes from AIDS patients. In: Clinical Immunology and Immunopathology. 1990 ; Vol. 54, No. 1. pp. 1-13.
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