A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

Janet L. Lathey, Jan M. Agosti, Jay A. Nelson, Lawrence Corey, Susan A. Gregory, James H. Morrissey, Thomas S. Edgington, Michael B.A. Oldstone

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalClinical Immunology and Immunopathology
Volume54
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Fingerprint Dive into the research topics of 'A selective defect in tissue factor mRNA expression in monocytes from AIDS patients'. Together they form a unique fingerprint.

  • Cite this

    Lathey, J. L., Agosti, J. M., Nelson, J. A., Corey, L., Gregory, S. A., Morrissey, J. H., Edgington, T. S., & Oldstone, M. B. A. (1990). A selective defect in tissue factor mRNA expression in monocytes from AIDS patients. Clinical Immunology and Immunopathology, 54(1), 1-13. https://doi.org/10.1016/0090-1229(90)90001-7