A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Fang Yuan, Steven H.L. Verhelst, Galia Blum, Lisa M. Coussens, Matthew Bogyo

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

Original languageEnglish (US)
Pages (from-to)5616-5617
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number17
DOIs
StatePublished - May 3 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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