A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

Patricia I. Fields, Eduardo A. Groisman, Fred Heffron

    Research output: Contribution to journalArticle

    379 Scopus citations

    Abstract

    Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

    Original languageEnglish (US)
    Pages (from-to)1059-1062
    Number of pages4
    JournalScience
    Volume243
    Issue number4894
    DOIs
    StatePublished - Jan 1 1989

    ASJC Scopus subject areas

    • General

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