A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

Patricia I. Fields; Eduardo A. Groisman; Fred Heffron

doi:10.1126/science.2646710

A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

Patricia I. Fields, Eduardo A. Groisman, Fred Heffron

Research output: Contribution to journal › Article › peer-review

423 Scopus citations

Abstract

Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

Original language	English (US)
Pages (from-to)	1059-1062
Number of pages	4
Journal	Science
Volume	243
Issue number	4894
DOIs	https://doi.org/10.1126/science.2646710
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.2646710

Cite this

@article{fc3d5fb9667e4c9c840c7b1443bcf4cc,

title = "A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells",

abstract = "Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.",

author = "Fields, {Patricia I.} and Groisman, {Eduardo A.} and Fred Heffron",

year = "1989",

doi = "10.1126/science.2646710",

language = "English (US)",

volume = "243",

pages = "1059--1062",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4894",

}

TY - JOUR

T1 - A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

AU - Fields, Patricia I.

AU - Groisman, Eduardo A.

AU - Heffron, Fred

PY - 1989

Y1 - 1989

N2 - Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

AB - Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

UR - http://www.scopus.com/inward/record.url?scp=0024601077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024601077&partnerID=8YFLogxK

U2 - 10.1126/science.2646710

DO - 10.1126/science.2646710

M3 - Article

C2 - 2646710

AN - SCOPUS:0024601077

SN - 0036-8075

VL - 243

SP - 1059

EP - 1062

JO - Science

JF - Science

IS - 4894

ER -

A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this