A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

Patricia I. Fields, Eduardo A. Groisman, Fred Heffron

Research output: Contribution to journalArticle

371 Citations (Scopus)

Abstract

Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

Original languageEnglish (US)
Pages (from-to)1059-1062
Number of pages4
JournalScience
Volume243
Issue number4894
StatePublished - 1989
Externally publishedYes

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Internal-External Control
Phagocytes
Salmonella
Virulence
Defensins
Defense Mechanisms
Salmonella typhimurium
Genes
Proteins
Health

ASJC Scopus subject areas

  • General

Cite this

Fields, P. I., Groisman, E. A., & Heffron, F. (1989). A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. Science, 243(4894), 1059-1062.

A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. / Fields, Patricia I.; Groisman, Eduardo A.; Heffron, Fred.

In: Science, Vol. 243, No. 4894, 1989, p. 1059-1062.

Research output: Contribution to journalArticle

Fields, PI, Groisman, EA & Heffron, F 1989, 'A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells', Science, vol. 243, no. 4894, pp. 1059-1062.
Fields, Patricia I. ; Groisman, Eduardo A. ; Heffron, Fred. / A salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. In: Science. 1989 ; Vol. 243, No. 4894. pp. 1059-1062.
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