A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Jonathan C. Savage, Pushkar Shinde, Hans Peter Bächinger, Monika A. Davare, Ujwal Shinde

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Spinach aptamer fluorescence requires formation of a tripartite complex composed of folded RNA, a GFP-like fluorophore, and selective cation coordination. 2′F pyrimidine modified Spinach has retained fluorescence, increased chemical stability, and accelerated cation association via increased G-quadruplex dynamics, thereby reducing readout time and enhancing Spinach utility for aqueous Pb2+ detection.

Original languageEnglish (US)
Pages (from-to)5882-5885
Number of pages4
JournalChemical Communications
Volume55
Issue number42
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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