A review of the role of glial cells in understanding retinal disease

Invited Review

Erica L. Fletcher, Laura E. Downie, Alice Ly, Michelle M. Ward, Abrez H. Batcha, Teresa Puthussery, Peter Yee, Kate M. Hatzopoulos

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Retinal vascular diseases such as diabetic retinopathy and retinopathy of prematurity are major causes of visual loss. Although the focus of a great deal of research has been on the aetiology of vascular growth, it is now emerging that anomalies in other retinal cell types, especially glial cells, occur very early in the course of the disease. Glial cells have major roles in every stage of disease, from the earliest subtle variations in neural function, to the development of epi-retinal membranes and tractional detachment. Therefore, having a firm understanding of the function of retinal glia is important in our understanding of retinal disease and is crucial for the development of new treatment strategies.

Original languageEnglish (US)
Pages (from-to)67-77
Number of pages11
JournalClinical and Experimental Optometry
Volume91
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Retinal Diseases
Neuroglia
Retinal Vessels
Retinopathy of Prematurity
Diabetic Retinopathy
Vascular Diseases
Blood Vessels
Membranes
Growth
Research

Keywords

  • Autoregulation
  • Diabetic retinopathy
  • Glial cell
  • Gliosis
  • Neurovascular
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Fletcher, E. L., Downie, L. E., Ly, A., Ward, M. M., Batcha, A. H., Puthussery, T., ... Hatzopoulos, K. M. (2008). A review of the role of glial cells in understanding retinal disease: Invited Review. Clinical and Experimental Optometry, 91(1), 67-77. https://doi.org/10.1111/j.1444-0938.2007.00204.x

A review of the role of glial cells in understanding retinal disease : Invited Review. / Fletcher, Erica L.; Downie, Laura E.; Ly, Alice; Ward, Michelle M.; Batcha, Abrez H.; Puthussery, Teresa; Yee, Peter; Hatzopoulos, Kate M.

In: Clinical and Experimental Optometry, Vol. 91, No. 1, 01.2008, p. 67-77.

Research output: Contribution to journalArticle

Fletcher, EL, Downie, LE, Ly, A, Ward, MM, Batcha, AH, Puthussery, T, Yee, P & Hatzopoulos, KM 2008, 'A review of the role of glial cells in understanding retinal disease: Invited Review', Clinical and Experimental Optometry, vol. 91, no. 1, pp. 67-77. https://doi.org/10.1111/j.1444-0938.2007.00204.x
Fletcher, Erica L. ; Downie, Laura E. ; Ly, Alice ; Ward, Michelle M. ; Batcha, Abrez H. ; Puthussery, Teresa ; Yee, Peter ; Hatzopoulos, Kate M. / A review of the role of glial cells in understanding retinal disease : Invited Review. In: Clinical and Experimental Optometry. 2008 ; Vol. 91, No. 1. pp. 67-77.
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