A review of genome-wide approaches to study the genetic basis for spermatogenic defects

Kenneth I. Aston, Donald F. Conrad

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations

Abstract

Rapidly advancing tools for genetic analysis on a genome-wide scale have been instrumental in identifying the genetic bases for many complex diseases. About half of male infertility cases are of unknown etiology in spite of tremendous efforts to characterize the genetic basis for the disorder. Advancing our understanding of the genetic basis for male infertility will require the application of established and emerging genomic tools. This chapter introduces many of the tools available for genetic studies on a genome-wide scale along with principles of study design and data analysis.

Original languageEnglish (US)
Title of host publicationBiomolecular Simulations
Subtitle of host publicationBiomolecular Simulations
PublisherHumana Press Inc.
Pages397-410
Number of pages14
ISBN (Print)9781627030373
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume927
ISSN (Print)1064-3745

Keywords

  • GWA
  • Male infertility
  • Microarray
  • Next-generation sequencing
  • Sperm
  • Whole genome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Aston, K. I., & Conrad, D. F. (2013). A review of genome-wide approaches to study the genetic basis for spermatogenic defects. In Biomolecular Simulations: Biomolecular Simulations (pp. 397-410). (Methods in Molecular Biology; Vol. 927). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-38-0_34