A retrospective study of AIDS-associated cryptomeningitis

Ravinder Kaur Sachdeva, Shivani Randev, Aman Sharma, Ajay Wanchu, Arunaloke Chakrabarti, Surjit Singh, Subhash Varma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cryptococcal meningitis has emerged as a leading cause of infectious morbidity and mortality in patients with AIDS. A retrospective analysis of records of HIV-infected individuals registered in the Immunodeficiency Clinic of a tertiary care hospital and research institute was carried out. Records of 6900 HIV-infected individuals who were enrolled in the clinic between January 2002 and March 2011 were analyzed. Records of 6900 HIV-infected individuals were screened. Ninety-one were diagnosed with cryptococcal meningitis (1.32%). In 68 individuals cryptococcal meningitis was the presenting illness. Nine patients developed meningitis within 6 months of starting antiretroviral treatment (ART). Six patients were receiving ART for more than 6 months at the time of diagnosis. The remaining eight patients were not on ART at the time of development of meningitis. The mean baseline CD4 count of patients was 77.7±61 (range, 4-259, n=91) cells/mm3. Seventy-four patients had a CD4 value of less than 100 at the time of diagnosis of cryptococcal meningitis. Eleven of these ninety-one patients had a relapse of cryptococcal meningitis while receiving a maintenance dose of fluconazole. During follow-up 37 died, two were lost to follow-up, while 52 patients were on regular ART. Mortality due to cryptococcal meningitis amounted to 0.54% (37/6900). There was no correlation between survival and duration of ART at the time of cryptomeningitis (Pearsons χ2=0.241, p=0.884). There was a significant difference in the CD4 counts of the HIV-infected individuals who died with cryptomeningitis and those who survived (Pearson's χ2=9.1, df=4, p=0.05). The frequency of cryptococcal meningitis was 1.32%. Cryptococcal meningitis leads to high mortality in HIV patients. Management of cryptococcal infection remains a key facet of AIDS care in India.

Original languageEnglish (US)
Pages (from-to)1220-1226
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Fingerprint

Cryptococcal Meningitis
Acquired Immunodeficiency Syndrome
Retrospective Studies
HIV
CD4 Lymphocyte Count
Meningitis
Mortality
Therapeutics
Fluconazole
Lost to Follow-Up
Tertiary Healthcare
Tertiary Care Centers
India
Morbidity
Recurrence
Survival

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Sachdeva, R. K., Randev, S., Sharma, A., Wanchu, A., Chakrabarti, A., Singh, S., & Varma, S. (2012). A retrospective study of AIDS-associated cryptomeningitis. AIDS Research and Human Retroviruses, 28(10), 1220-1226. https://doi.org/10.1089/aid.2011.0293

A retrospective study of AIDS-associated cryptomeningitis. / Sachdeva, Ravinder Kaur; Randev, Shivani; Sharma, Aman; Wanchu, Ajay; Chakrabarti, Arunaloke; Singh, Surjit; Varma, Subhash.

In: AIDS Research and Human Retroviruses, Vol. 28, No. 10, 01.10.2012, p. 1220-1226.

Research output: Contribution to journalArticle

Sachdeva, RK, Randev, S, Sharma, A, Wanchu, A, Chakrabarti, A, Singh, S & Varma, S 2012, 'A retrospective study of AIDS-associated cryptomeningitis', AIDS Research and Human Retroviruses, vol. 28, no. 10, pp. 1220-1226. https://doi.org/10.1089/aid.2011.0293
Sachdeva RK, Randev S, Sharma A, Wanchu A, Chakrabarti A, Singh S et al. A retrospective study of AIDS-associated cryptomeningitis. AIDS Research and Human Retroviruses. 2012 Oct 1;28(10):1220-1226. https://doi.org/10.1089/aid.2011.0293
Sachdeva, Ravinder Kaur ; Randev, Shivani ; Sharma, Aman ; Wanchu, Ajay ; Chakrabarti, Arunaloke ; Singh, Surjit ; Varma, Subhash. / A retrospective study of AIDS-associated cryptomeningitis. In: AIDS Research and Human Retroviruses. 2012 ; Vol. 28, No. 10. pp. 1220-1226.
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