A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen; J. A. Frank; N. R. Johnston; R. K. Mitchell; K. Šmid; P. Marchetti; M. Bugliani; G. A. Rutter; D. Trauner; D. J. Hodson

doi:10.1039/c5cc01224d

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen, J. A. Frank, N. R. Johnston, R. K. Mitchell, K. Šmid, P. Marchetti, M. Bugliani, G. A. Rutter, D. Trauner, D. J. Hodson

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

Original language	English (US)
Pages (from-to)	6018-6021
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	27
DOIs	https://doi.org/10.1039/c5cc01224d
State	Published - Apr 7 2015
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc01224d

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title = "A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function",

abstract = "Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.",

author = "J. Broichhagen and Frank, {J. A.} and Johnston, {N. R.} and Mitchell, {R. K.} and K. {\v S}mid and P. Marchetti and M. Bugliani and Rutter, {G. A.} and D. Trauner and Hodson, {D. J.}",

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doi = "10.1039/c5cc01224d",

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T1 - A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

AU - Broichhagen, J.

AU - Frank, J. A.

AU - Johnston, N. R.

AU - Mitchell, R. K.

AU - Šmid, K.

AU - Marchetti, P.

AU - Bugliani, M.

AU - Rutter, G. A.

AU - Trauner, D.

AU - Hodson, D. J.

PY - 2015/4/7

Y1 - 2015/4/7

N2 - Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

AB - Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

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EP - 6021

JO - Chemical Communications

JF - Chemical Communications

IS - 27

ER -

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Abstract

ASJC Scopus subject areas

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