Abstract
The reaction of hemimellitic acid (1) with SF4/HF gives a 1 : 3.5 : 13 mixture of 1,2,3-tris(trifluoromethyl)benzene (2), 1,1,3,3-tetrafluoro-4-trifluoromethyl-1,3-dihydroisobenzofuran (3) and 2,6-bis(trifluoromethyl)benzoyl fluoride (4). Treatment of the crude reaction mixture with aqueous KOH, followed by acidification of the water phase, gives a good yield of pure 2,6-bis(trifluoromethyl)benzoic acid (5).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-165 |
| Number of pages | 3 |
| Journal | Journal of Fluorine Chemistry |
| Volume | 82 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1997 |
| Externally published | Yes |
Keywords
- 1,1,3,3-Tetrafluoro-4-trifluoromethyl-1,3-dihydroisobenzofuran
- 1,2,3-Tris(trifluoromethyl)benzene
- 2,6-Bis(trifluoromethyl)benzoic acid
- 2,6-Bis(trifluoromethyl)benzoyl fluoride
- Fluorination
- Hemimellitic acid
- Sulphur tetrafluoride
ASJC Scopus subject areas
- Biochemistry
- Environmental Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry