A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients impact on cardiovascular risk reduction

Jill A. Metz, Judith S. Stern, Penny Kris-Etherton, Molly E. Reusser, Cynthia Morris, Daniel C. Hatton, Suzanne Oparil, R. Brian Haynes, Lawrence M. Resnick, F. Xavier Pi-Sunyer, Sharon Clark, Leslie Chester, Margaret McMahon, Geoffrey W. Snyder, David A. McCarron

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139 Scopus citations

Abstract

Objective: To assess the long-term effects of a prepackaged, nutritionally complete, prepared meal plan compared with a usual-care diet (UCD) on weight loss and cardiovascular risk factors in overweight and obese persons. Design: In this randomized multicenter study, 302 persons with hypertension and dyslipidemia (n = 183) or with type 2 diabetes mellitus (n = 119) were randomized to the nutrient-fortified prepared meal plan (approximately 22% energy from fat, 58% from carbohydrate, and 20% from protein) or to a macronutrient-equivalent UCD. Main Outcome Measures: The primary outcome measure was weight change. Secondary measures were changes in blood pressure or plasma lipid, lipoprotein, glucose, or glycosylated hemoglobin levels; quality of life; nutrient intake; and dietary compliance. Results: After 1 year, weight change in the hypertension/dyslipidemia group was -5.8 ± 6.8 kg with the prepared meal plan vs -1.7 ± 6.5 kg with the UCD plan (P

Original languageEnglish (US)
Pages (from-to)2150-2158
Number of pages9
JournalArchives of Internal Medicine
Volume160
Issue number14
Publication statusPublished - Jul 24 2000

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ASJC Scopus subject areas

  • Internal Medicine

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Metz, J. A., Stern, J. S., Kris-Etherton, P., Reusser, M. E., Morris, C., Hatton, D. C., ... McCarron, D. A. (2000). A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients impact on cardiovascular risk reduction. Archives of Internal Medicine, 160(14), 2150-2158.