A randomized split-mouth clinical trial on effectiveness of amnion-chorion membranes in alveolar ridge preservation: A clinical, radiologic, and morphometric study

Muyeenul Hassan, Sivaraman Prakasam, Carol Bain, Ahmed Ghoneima, Sean Shih Yao Liu

Research output: Contribution to journalArticle

6 Scopus citations


Purpose: Recent case reports suggest that amnion-chorion membranes (ACM) and dense polytetrafluoroethylene membranes (dPTFE) can be left exposed during ridge preservation. The aim of this study was to compare the effectiveness of these membranes in ridge preservation, particularly when they are intentionally left exposed. Materials and Methods: A split-mouth, single-blind, randomized trial design was used to compare treatments with the two membranes in 22 nonmolar sites on the same arch. Ridge dimensions were recorded clinically and with cone beam computed tomography prior to and 3 months after ridge preservation. Postoperative discomfort was recorded with Visual Analog Scale (VAS) forms. Mixed-model analysis of variance was used to test significance. Results: Clinical and radiographic ridge dimensions were not significantly different between the two treatments. ACM sites had significantly more osteoid and higher bone volume density but significantly less graft particles and bone surface density compared with dPTFE. Mineralized bone area and soft tissue area were not significantly different between the two treatments. ACM sites had significantly lower postoperative VAS scores compared with dPTFE. Conclusion: Intentionally exposed ACM is equally effective in ridge preservation compared with dPTFE. Additionally, ACM use may aid in reducing postoperative VAS scores, and potentially result in better quality of bone available for implant placement, as evidenced by improved histomorphometric measures.

Original languageEnglish (US)
Pages (from-to)1389-1398
Number of pages10
JournalInternational Journal of Oral and Maxillofacial Implants
Issue number6
Publication statusPublished - Jan 1 2017



  • Amnion-chorion membrane
  • Cone beam computed tomography
  • Dense PTFE
  • Histomorphometry
  • Microtomography
  • RCT
  • Ridge preservation

ASJC Scopus subject areas

  • Oral Surgery

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