A randomized double blind trial of t-cell depletion with cds/8 cellector(r) in addition to cyclosporin, methotrexate and steroids fcn acute graft versus host disease prevention in hla mismatched bone marrow transplant

J. Gajewski, D. Wall, D. Adkins, R. Geller, A. Yver, K. Llovd, S. Souza, R. Chamolin

Research output: Contribution to journalArticle

Abstract

Acute graft versus host disease(AGVHD) is a major cuuse cf mortality in mismatched(MM) bone marrow transplant(BMT). T-eoil depletion(TCD) reduces AGVHD but increases relapse & rejection. 61 patients treated with MM BMT using total body irradiat'cn, cyclophosphamide, thiotepa, antithymocyte globulin with cyclospc., methotrexate and steroids for AGVHD prophylaxis were random. I for partial TCD. Stratification is reviewed below. TRANSPLANT TYPE TCD CONTROL Mismatched Related 1 6 Matched Unrelated Donor 26 22 Mismatched Unrelated Donor 4 2 DISEASE STAGE Good Risk Disease 17 18 Poor Risk Disease 14 12. AGE mean (range) 29 (1-51) 30 (2-51) Good risk disease was CML in first chronic phc.se cr acute leukemia in 1 to 2 complete relapse. Results are reviev,0J below. TCD CONTROL P-Valv? 100 day Actuarial 0.24(0.05,0.44) 0.67(0.49,0.8s1 O.CCCC Gradelll/IV AGVHD 9 month Actuarial 0.26(0.10,0.42) 0.17(0.03,0.30) 0.43 Overall Survival Cox regression for severe AGVHD revealed partial TCD improved outcome (p=0.002). 9 month overall survival was affected by patient age (p=0.018). In conclusion, partial TCD reduced the risk of severe AGVHD; the effect on survival requires longer follow-up.

Original languageEnglish (US)
Pages (from-to)813
Number of pages1
JournalExperimental Hematology
Volume25
Issue number8
Publication statusPublished - 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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