A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets

Nancy M. Heddle, Luba Klama, Ralph Meyer, Irwin Walker, Lynn Boshkov, Robin Roberts, Shelley Chambers, Linda Podlosky, Pamela O'Hoski, Mark Levine

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

BACKGROUND: Recent data suggest that most reactions to platelets are caused by white cell (WBC)-derived cytokines that accumulate in the plasma portion of the component during storage. On the basis of this theory, the effectiveness of two interventions to prevent reactions, poststorage WBC reduction and plasma depletion, were compared. STUDY DESIGN: A multiple crossover design was used, in which platelet components for transfusion to a patient randomly were WBC reduced after storage, or the plasma supernatant was removed. Adults >17 years of age, with a hematologic disease requiring platelet transfusion support, were eligible for the study. Patients were assessed for signs and symptoms characteristic of a reaction during, immediately after, and 1 hour after transfusion. Reactions were graded as mild, moderate, or severe. Interleukin 6 levels were also measured in the transfused platelet components. RESULTS: There were 380 analyzable platelet transfusions to 30 patients. The frequency of reactions was 25.8 percent (48/186) in the transfusions of poststorage WBC-reduced platelets and 17.0 percent (33/194) in the transfusions of plasma-depleted platelets (p

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalTransfusion
Volume39
Issue number3
StatePublished - 1999
Externally publishedYes

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Platelet Transfusion
Blood Platelets
Randomized Controlled Trials
Hematologic Diseases
Cross-Over Studies
Signs and Symptoms
Interleukin-6
Cytokines

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Heddle, N. M., Klama, L., Meyer, R., Walker, I., Boshkov, L., Roberts, R., ... Levine, M. (1999). A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets. Transfusion, 39(3), 231-238.

A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets. / Heddle, Nancy M.; Klama, Luba; Meyer, Ralph; Walker, Irwin; Boshkov, Lynn; Roberts, Robin; Chambers, Shelley; Podlosky, Linda; O'Hoski, Pamela; Levine, Mark.

In: Transfusion, Vol. 39, No. 3, 1999, p. 231-238.

Research output: Contribution to journalArticle

Heddle, NM, Klama, L, Meyer, R, Walker, I, Boshkov, L, Roberts, R, Chambers, S, Podlosky, L, O'Hoski, P & Levine, M 1999, 'A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets', Transfusion, vol. 39, no. 3, pp. 231-238.
Heddle NM, Klama L, Meyer R, Walker I, Boshkov L, Roberts R et al. A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets. Transfusion. 1999;39(3):231-238.
Heddle, Nancy M. ; Klama, Luba ; Meyer, Ralph ; Walker, Irwin ; Boshkov, Lynn ; Roberts, Robin ; Chambers, Shelley ; Podlosky, Linda ; O'Hoski, Pamela ; Levine, Mark. / A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets. In: Transfusion. 1999 ; Vol. 39, No. 3. pp. 231-238.
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AU - Walker, Irwin

AU - Boshkov, Lynn

AU - Roberts, Robin

AU - Chambers, Shelley

AU - Podlosky, Linda

AU - O'Hoski, Pamela

AU - Levine, Mark

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