A randomized clinical trial to evaluate home-based assessment of people over 75 years old

Alzheimer Disease Cooperative Study Investigators

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: There is an unmet need for effective methods for conducting dementia prevention trials. Methods: Home-based assessment study compared feasibility and efficiency, ability to capture change over time using in-home instruments, and ability to predict cognitive conversion using predefined triggers in a randomized clinical trial in (1)mail-in questionnaire/live telephone interviews, (2)automated telephone/interactive voice recognition, and (3)internet-based computer Kiosk technologies. Primary endpoint was defined as cognitive conversion. Results: Analysis followed a modified intent-to-treat principle. Dropout rates were low and similar across technologies but participants in Kiosk were more likely to dropout earlier. Staff resources needed were higher in Kiosk. In-home instruments distinguished conversion and stable groups. Cognitively stable group showed improvement in cognitive measures. Triggering was associated with higher likelihood of conversion but statistically significant only in mail-in questionnaire/live telephone interviews. Discussion: Relatively low efficiency of internet-based assessment compared with testing by live-assessors has implications for internet-based recruitment and assessment efforts currently proposed for diverse populations.

Original languageEnglish (US)
Pages (from-to)615-624
Number of pages10
JournalAlzheimer's and Dementia
Volume15
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Alzheimer's disease
  • Dementia prevention
  • Home-based assessment
  • Randomized clinical trial

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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