A radiosynthesis of fluorine-18 fluoromisonidazole

J. R. Grierson, J. M. Link, C. A. Mathis, J. S. Rasey, K. A. Krohn

Research output: Contribution to journalArticle

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Abstract

A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of > 650 Ci/mmol (EOB) and a synthesis time of ~ 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalJournal of Nuclear Medicine
Volume30
Issue number3
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Grierson, J. R., Link, J. M., Mathis, C. A., Rasey, J. S., & Krohn, K. A. (1989). A radiosynthesis of fluorine-18 fluoromisonidazole. Journal of Nuclear Medicine, 30(3), 343-350.