Abstract
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of > 650 Ci/mmol (EOB) and a synthesis time of ~ 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.
Original language | English (US) |
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Pages (from-to) | 343-350 |
Number of pages | 8 |
Journal | Journal of Nuclear Medicine |
Volume | 30 |
Issue number | 3 |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging