A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections

R. Tolle, Klaus Frueh, O. Doumbo, O. Koita, M. N'Diaye, A. Fischer, K. Dietz, H. Bujard

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection against and/or control of parasitemia were, however, found for adolescents and adults, respectively. Thus, in adolescents, the presence of antibodies to gp190 fragment M6 correlates with a 50% reduced risk of P. falciparum infection and an increased ability to control parasitemia, whereas in adults, the humoral response to some of the polymorphic regions of gp190 associates with an increased risk of infection.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalInfection and Immunity
Volume61
Issue number1
StatePublished - 1993
Externally publishedYes

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Parasitemia
Plasmodium falciparum
Humoral Immunity
Infection Control
Malaria
Prospective Studies
Communicable Disease Control
Merozoites
Antigens
Antibody Specificity
Antibodies
Surface Antigens
Infection
Parasites

ASJC Scopus subject areas

  • Immunology

Cite this

A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections. / Tolle, R.; Frueh, Klaus; Doumbo, O.; Koita, O.; N'Diaye, M.; Fischer, A.; Dietz, K.; Bujard, H.

In: Infection and Immunity, Vol. 61, No. 1, 1993, p. 40-47.

Research output: Contribution to journalArticle

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AU - N'Diaye, M.

AU - Fischer, A.

AU - Dietz, K.

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