A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata

Lynn Marshall, Donna Spiegelman, Marlene B. Goldman, JoAnn E. Manson, Graham A. Colditz, Robert L. Barbieri, Meir J. Stampfer, David J. Hunter

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

Objective: To investigate the risk of uterine leiomyomata in relation to reproductive factors and oral contraceptive use. Design: A prospective study. Setting: A cohort of female registered nurses from 14 states in the United States who completed mailed questionnaires in 1989, 1991, and 1993. Patient(s): Premenopausal nurses (n = 95,061) aged 25-42 years with intact uteri and no history of diagnosed uterine leiomyomata or cancer in 1989. Intervention(s): None. Main Outcome Measure(s): Incidence of self-reported uterine leiomyomata confirmed by ultrasound or hysterectomy. In a sample of 243 cases, 93% of the self-reported diagnoses were confirmed in the medical record. Result(s): During 326,116 person-years of follow-up, 3,006 cases of uterine leiomyomata, confirmed by ultrasound or hysterectomy, were reported. After adjustment for other risk factors, the risk of uterine leiomyomata was significantly inversely associated with age at menarche, parity, and age at first birth, and positively associated with a history of infertility and years since last birth. The only notable association with any aspect of oral contraceptive use was a significantly elevated risk among women who first used oral contraceptives at ages 13-16 years compared with those who had never used oral contraceptives. Conclusion(s): Reproductive factors and oral contraceptive use at a young age influence the risk of uterine leiomyomata among premenopausal women.

Original languageEnglish (US)
Pages (from-to)432-439
Number of pages8
JournalFertility and Sterility
Volume70
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Leiomyoma
Oral Contraceptives
Prospective Studies
Hysterectomy
Nurses
Uterine Neoplasms
Menarche
Birth Order
Parity
Infertility
Uterus
Medical Records
Outcome Assessment (Health Care)
Parturition
Incidence

Keywords

  • Cohort studies
  • Infertility
  • Leiomyoma
  • Menarche
  • Oral contraceptives
  • Pregnancy
  • Uterine neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. / Marshall, Lynn; Spiegelman, Donna; Goldman, Marlene B.; Manson, JoAnn E.; Colditz, Graham A.; Barbieri, Robert L.; Stampfer, Meir J.; Hunter, David J.

In: Fertility and Sterility, Vol. 70, No. 3, 1998, p. 432-439.

Research output: Contribution to journalArticle

Marshall, L, Spiegelman, D, Goldman, MB, Manson, JE, Colditz, GA, Barbieri, RL, Stampfer, MJ & Hunter, DJ 1998, 'A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata', Fertility and Sterility, vol. 70, no. 3, pp. 432-439. https://doi.org/10.1016/S0015-0282(98)00208-8
Marshall, Lynn ; Spiegelman, Donna ; Goldman, Marlene B. ; Manson, JoAnn E. ; Colditz, Graham A. ; Barbieri, Robert L. ; Stampfer, Meir J. ; Hunter, David J. / A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. In: Fertility and Sterility. 1998 ; Vol. 70, No. 3. pp. 432-439.
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