A prospective randomized comparison of extensive prostate biopsy to standard biopsy with assessment of diagnostic yield, biopsy pain and morbidity

R. L. Sur, P. G. Borboroglu, J. L. Roberts, C. L. Amling

Research output: Contribution to journalArticle

9 Scopus citations


In a prospective randomized study, we compare standard prostate biopsy to extensive biopsy utilizing intravenous conscious sedation (IVCS). Initial biopsy patients (n = 197) were randomized to either standard biopsy using intrarectal lidocaine gel (6-12 biopsies, mean 10.1) or extensive biopsy (24 biopsies) using IVCS. Cancer detection and urinary symptoms were no different between groups. However, biopsy pain was rated significantly lower and satisfaction significantly higher in the extensive biopsy group. Temporary urinary retention occurred in 4% of the extensive biopsy group. Extended biopsy with 24 samples does not improve cancer detection compared to standard biopsy when 10 cores are obtained. Extensive biopsy is very well tolerated and associated with less pain and more satisfaction than standard biopsy.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Issue number2
StatePublished - Jul 28 2004



  • Anesthesia
  • Prostate biopsy

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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