A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers

Does physician specialty matter?

Sweet Ping Ng, Brandon A. Dyer, Jayashree Kalpathy-Cramer, Abdallah Sherif Radwan Mohamed, Musaddiq J. Awan, G. Brandon Gunn, Jack Phan, Mark Zafereo, J. Matthew Debnam, Carol M. Lewis, Rivka R. Colen, Michael E. Kupferman, Nandita Guha-Thakurta, Guadalupe Canahuate, G. Elisabeta Marai, David Vock, Bronwyn Hamilton, John Holland, Carlos E. Cardenas, Stephen Lai & 2 others David Rosenthal, Clifton David Fuller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of this study was to determine the interdisciplinary agreement in identifying the post-operative tumor bed. Methods: Three radiation oncologists (ROs), four surgeons, and three radiologists segmented post-operative tumor and nodal beds for three patients with oral cavity cancer. Specialty cohort composite contours were created by STAPLE algorithm implementation results for interspecialty comparison. Dice similarity coefficient and Hausdorff distance were utilized to compare spatial differentials between specialties. Results: There were significant differences between disciplines in target delineation. There was unacceptable variation in Dice similarity coefficient for each observer and discipline when compared to the STAPLE contours. Within surgery and radiology disciplines, there was good consistency in volumes. ROs and radiologists have similar Dice similarity coefficient scores compared to surgeons. Conclusion: There were significant interdisciplinary differences in perceptions of tissue-at-risk. Better communication and explicit description of at-risk areas between disciplines is required to ensure high-risk areas are adequately targeted.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalClinical and Translational Radiation Oncology
Volume12
DOIs
StatePublished - Aug 1 2018

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Observer Variation
Mouth Neoplasms
Computer Simulation
Mouth
Physicians
Radiology
Neoplasms
Communication
Radiation Oncologists
Radiologists
Surgeons

Keywords

  • Interdisciplinary
  • Interobserver
  • Oral cavity cancer
  • Post-operative
  • Target delineation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers : Does physician specialty matter? / Ng, Sweet Ping; Dyer, Brandon A.; Kalpathy-Cramer, Jayashree; Mohamed, Abdallah Sherif Radwan; Awan, Musaddiq J.; Gunn, G. Brandon; Phan, Jack; Zafereo, Mark; Debnam, J. Matthew; Lewis, Carol M.; Colen, Rivka R.; Kupferman, Michael E.; Guha-Thakurta, Nandita; Canahuate, Guadalupe; Marai, G. Elisabeta; Vock, David; Hamilton, Bronwyn; Holland, John; Cardenas, Carlos E.; Lai, Stephen; Rosenthal, David; Fuller, Clifton David.

In: Clinical and Translational Radiation Oncology, Vol. 12, 01.08.2018, p. 40-46.

Research output: Contribution to journalArticle

Ng, SP, Dyer, BA, Kalpathy-Cramer, J, Mohamed, ASR, Awan, MJ, Gunn, GB, Phan, J, Zafereo, M, Debnam, JM, Lewis, CM, Colen, RR, Kupferman, ME, Guha-Thakurta, N, Canahuate, G, Marai, GE, Vock, D, Hamilton, B, Holland, J, Cardenas, CE, Lai, S, Rosenthal, D & Fuller, CD 2018, 'A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers: Does physician specialty matter?', Clinical and Translational Radiation Oncology, vol. 12, pp. 40-46. https://doi.org/10.1016/j.ctro.2018.07.006
Ng, Sweet Ping ; Dyer, Brandon A. ; Kalpathy-Cramer, Jayashree ; Mohamed, Abdallah Sherif Radwan ; Awan, Musaddiq J. ; Gunn, G. Brandon ; Phan, Jack ; Zafereo, Mark ; Debnam, J. Matthew ; Lewis, Carol M. ; Colen, Rivka R. ; Kupferman, Michael E. ; Guha-Thakurta, Nandita ; Canahuate, Guadalupe ; Marai, G. Elisabeta ; Vock, David ; Hamilton, Bronwyn ; Holland, John ; Cardenas, Carlos E. ; Lai, Stephen ; Rosenthal, David ; Fuller, Clifton David. / A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers : Does physician specialty matter?. In: Clinical and Translational Radiation Oncology. 2018 ; Vol. 12. pp. 40-46.
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AU - Kalpathy-Cramer, Jayashree

AU - Mohamed, Abdallah Sherif Radwan

AU - Awan, Musaddiq J.

AU - Gunn, G. Brandon

AU - Phan, Jack

AU - Zafereo, Mark

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AU - Kupferman, Michael E.

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AU - Marai, G. Elisabeta

AU - Vock, David

AU - Hamilton, Bronwyn

AU - Holland, John

AU - Cardenas, Carlos E.

AU - Lai, Stephen

AU - Rosenthal, David

AU - Fuller, Clifton David

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N2 - Background: The aim of this study was to determine the interdisciplinary agreement in identifying the post-operative tumor bed. Methods: Three radiation oncologists (ROs), four surgeons, and three radiologists segmented post-operative tumor and nodal beds for three patients with oral cavity cancer. Specialty cohort composite contours were created by STAPLE algorithm implementation results for interspecialty comparison. Dice similarity coefficient and Hausdorff distance were utilized to compare spatial differentials between specialties. Results: There were significant differences between disciplines in target delineation. There was unacceptable variation in Dice similarity coefficient for each observer and discipline when compared to the STAPLE contours. Within surgery and radiology disciplines, there was good consistency in volumes. ROs and radiologists have similar Dice similarity coefficient scores compared to surgeons. Conclusion: There were significant interdisciplinary differences in perceptions of tissue-at-risk. Better communication and explicit description of at-risk areas between disciplines is required to ensure high-risk areas are adequately targeted.

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