A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation

Anna Christina Dela Cruz, Valery Vilchez, Sooyeon Kim, Benjamin Barnes, Abhishek Ravinuthala, Anthony Zanni, Roberto Galuppo, Achuthan Sourianarayanane, Trushar Patel, Erin Maynard, Malay B. Shah, Michael F. Daily, Timothy Uhl, Karyn Esser, Roberto Gedaly

Research output: Contribution to journalArticle

Abstract

Background: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods: Single-center, prospective analysis. Results: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005). Conclusions: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.

Original languageEnglish (US)
Pages (from-to)958-964
Number of pages7
JournalClinical Transplantation
Volume29
Issue number11
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Fingerprint

Statistical Factor Analysis
Hand Strength
Fibrosis
Exercise
Transplants
End Stage Liver Disease
Smoking
Metabolic Equivalent
Alcoholic Liver Diseases
Fatty Liver
Hepatitis C
Liver Cirrhosis
Liver Diseases
Transplantation
Muscles
Liver

Keywords

  • Cirrhosis
  • Grip strength
  • Liver transplantation
  • Physical activity

ASJC Scopus subject areas

  • Transplantation

Cite this

A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation. / Dela Cruz, Anna Christina; Vilchez, Valery; Kim, Sooyeon; Barnes, Benjamin; Ravinuthala, Abhishek; Zanni, Anthony; Galuppo, Roberto; Sourianarayanane, Achuthan; Patel, Trushar; Maynard, Erin; Shah, Malay B.; Daily, Michael F.; Uhl, Timothy; Esser, Karyn; Gedaly, Roberto.

In: Clinical Transplantation, Vol. 29, No. 11, 01.11.2015, p. 958-964.

Research output: Contribution to journalArticle

Dela Cruz, AC, Vilchez, V, Kim, S, Barnes, B, Ravinuthala, A, Zanni, A, Galuppo, R, Sourianarayanane, A, Patel, T, Maynard, E, Shah, MB, Daily, MF, Uhl, T, Esser, K & Gedaly, R 2015, 'A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation', Clinical Transplantation, vol. 29, no. 11, pp. 958-964. https://doi.org/10.1111/ctr.12602
Dela Cruz, Anna Christina ; Vilchez, Valery ; Kim, Sooyeon ; Barnes, Benjamin ; Ravinuthala, Abhishek ; Zanni, Anthony ; Galuppo, Roberto ; Sourianarayanane, Achuthan ; Patel, Trushar ; Maynard, Erin ; Shah, Malay B. ; Daily, Michael F. ; Uhl, Timothy ; Esser, Karyn ; Gedaly, Roberto. / A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation. In: Clinical Transplantation. 2015 ; Vol. 29, No. 11. pp. 958-964.
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abstract = "Background: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods: Single-center, prospective analysis. Results: One hundred patients were evaluated (54{\%} male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27{\%}), hepatitis C (22{\%}) and alcoholic liver disease (21{\%}). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95{\%} CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95{\%} CI 1.4-8, p = 0.005). Conclusions: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.",
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AU - Vilchez, Valery

AU - Kim, Sooyeon

AU - Barnes, Benjamin

AU - Ravinuthala, Abhishek

AU - Zanni, Anthony

AU - Galuppo, Roberto

AU - Sourianarayanane, Achuthan

AU - Patel, Trushar

AU - Maynard, Erin

AU - Shah, Malay B.

AU - Daily, Michael F.

AU - Uhl, Timothy

AU - Esser, Karyn

AU - Gedaly, Roberto

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N2 - Background: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods: Single-center, prospective analysis. Results: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005). Conclusions: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.

AB - Background: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods: Single-center, prospective analysis. Results: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005). Conclusions: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.

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