A Prognostic Factor Study Of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma

Johanna M. Seddon, Daniel Albert, Nancy Robinson, Philip T. Lavin

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Prognostic indicators of uveal melanoma disease-free interval and survival following enucleation were evaluated for 267 patients. The median follow-up time was 17 years. Analysis involved Kaplan-Meier survival curves based on time to tumor-related deaths and multivariate proportional hazards analysis, which provides an estimate of the “force of mortality.” Prognostic indicators considered included demographic, clinical, and histopathological factors. Cell type was classified according to the number of epithelioid cells present per high-power field (HPF) on light microscopy. Various classifications of size of the tumor were compared for prognostic value. The five leading predictors of survival in order of importance were as follows: (1) number of epithelioid cells per HPF, (2) largest dimension of the tumor, (3) location of the anterior margin of the tumor, (4) invasion to the line of transection, and (5) degree of pigmentation. Risk categories for survival were constructed based on the three leading prognostic factors.

Original languageEnglish (US)
Pages (from-to)1894-1899
Number of pages6
JournalArchives of ophthalmology
Volume101
Issue number12
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Disease-Free Survival
Epithelioid Cells
Uveal Diseases
Neoplasms
Survival
Pigmentation
Kaplan-Meier Estimate
Microscopy
Demography
Light
Mortality
Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

A Prognostic Factor Study Of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma. / Seddon, Johanna M.; Albert, Daniel; Robinson, Nancy; Lavin, Philip T.

In: Archives of ophthalmology, Vol. 101, No. 12, 01.01.1983, p. 1894-1899.

Research output: Contribution to journalArticle

Seddon, Johanna M. ; Albert, Daniel ; Robinson, Nancy ; Lavin, Philip T. / A Prognostic Factor Study Of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma. In: Archives of ophthalmology. 1983 ; Vol. 101, No. 12. pp. 1894-1899.
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