We found that administration of increasing doses of ethinyl estradiol had a biphasic effect on ulnar growth rate. The relatively low dose of 100 ng per kilogram of body weight per day, given for one month, caused a doubling of the ulnar growth rate. Placebo and ethinyl estradiol doses of 400 to 800 ng per kilogram per day, however, caused no significant change. These results suggest that ethinyl estradiol in low doses increases ulnar growth rate and that standard replacement doses (400 to 1200 ng per kilogram per day) are not optimal for ulnar growth. The higher doses may actually impair the growth potential of patients with Turner's syndrome. Further studies will be required to explore the clinical implications of this work, but these preliminary findings suggest that low doses of estrogen may have long-term effects on growth in Turner's syndrome.
|Original language||English (US)|
|Number of pages||3|
|Journal||New England Journal of Medicine|
|Publication status||Published - 1983|
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