A preclinical murine model of hepatic metastases

Kevin C. Soares; Kelly Foley; Kelly Olino; Ashley Leubner; Skye C. Mayo; Ajay Jain; Richard D. Schulick; Elizabeth Jaffee; Kiyoshi Yoshimura; Barish Edil; Lei Zheng

doi:10.3791/51677

A preclinical murine model of hepatic metastases

Kevin C. Soares, Kelly Foley, Kelly Olino, Ashley Leubner, Skye C. Mayo, Ajay Jain, Richard D. Schulick, Elizabeth Jaffee, Kiyoshi Yoshimura, Barish Edil, Lei Zheng

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

Original language	English (US)
Article number	e51677
Journal	Journal of Visualized Experiments
Issue number	91
DOIs	https://doi.org/10.3791/51677
State	Published - Sep 27 2014
Externally published	Yes

Keywords

Hemispleen
Hepatic Metastases
Immunotherapy
Issue 91
Liver
Medicine
Metastatic
Murine
Pancreatic Cancer
Pancreatic Neoplasms
Preclinical Model

ASJC Scopus subject areas

General Neuroscience
General Chemical Engineering
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.3791/51677

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title = "A preclinical murine model of hepatic metastases",

abstract = "Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.",

keywords = "Hemispleen, Hepatic Metastases, Immunotherapy, Issue 91, Liver, Medicine, Metastatic, Murine, Pancreatic Cancer, Pancreatic Neoplasms, Preclinical Model",

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doi = "10.3791/51677",

language = "English (US)",

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T1 - A preclinical murine model of hepatic metastases

AU - Soares, Kevin C.

AU - Foley, Kelly

AU - Olino, Kelly

AU - Leubner, Ashley

AU - Mayo, Skye C.

AU - Jain, Ajay

AU - Schulick, Richard D.

AU - Jaffee, Elizabeth

AU - Yoshimura, Kiyoshi

AU - Edil, Barish

AU - Zheng, Lei

PY - 2014/9/27

Y1 - 2014/9/27

N2 - Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

AB - Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

KW - Hemispleen

KW - Hepatic Metastases

KW - Immunotherapy

KW - Issue 91

KW - Liver

KW - Medicine

KW - Metastatic

KW - Murine

KW - Pancreatic Cancer

KW - Pancreatic Neoplasms

KW - Preclinical Model

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DO - 10.3791/51677

M3 - Article

C2 - 25285458

AN - SCOPUS:84908330270

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JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

IS - 91

M1 - e51677

ER -

A preclinical murine model of hepatic metastases

Abstract

Keywords

ASJC Scopus subject areas

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