Abstract
We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-102 |
| Number of pages | 6 |
| Journal | Biochemical Medicine and Metabolic Biology |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1992 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
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Sweet, A., Erickson, R. P., Huntington, C., & Dawson, D. (1992). A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. Biochemical Medicine and Metabolic Biology, 47(1), 97-102. https://doi.org/10.1016/0885-4505(92)90011-M