Abstract
We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-102 |
| Number of pages | 6 |
| Journal | Biochemical Medicine and Metabolic Biology |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
A potential animal model for studying CF heterozygote advantage : Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. / Sweet, Ann; Erickson, Robert P.; Huntington, Caleb; Dawson, David.
In: Biochemical Medicine and Metabolic Biology, Vol. 47, No. 1, 1992, p. 97-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A potential animal model for studying CF heterozygote advantage
T2 - Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice
AU - Sweet, Ann
AU - Erickson, Robert P.
AU - Huntington, Caleb
AU - Dawson, David
PY - 1992
Y1 - 1992
N2 - We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.
AB - We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.
UR - http://www.scopus.com/inward/record.url?scp=0026593998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026593998&partnerID=8YFLogxK
U2 - 10.1016/0885-4505(92)90011-M
DO - 10.1016/0885-4505(92)90011-M
M3 - Article
VL - 47
SP - 97
EP - 102
JO - Molecular Genetics and Metabolism
JF - Molecular Genetics and Metabolism
SN - 1096-7192
IS - 1
ER -