A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet; Robert P. Erickson; Caleb Huntington; David Dawson

doi:10.1016/0885-4505(92)90011-M

A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet, Robert P. Erickson, Caleb Huntington, David Dawson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl^- secretion in the DBA 2J than in the C57BL 6J strain. Their F₁ showed significantly higher levels of Cl^- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F₁ values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.

Original language	English (US)
Pages (from-to)	97-102
Number of pages	6
Journal	Biochemical Medicine and Metabolic Biology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0885-4505(92)90011-M
State	Published - Feb 1992
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry

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10.1016/0885-4505(92)90011-M

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A potential animal model for studying CF heterozygote advantage : Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. / Sweet, Ann; Erickson, Robert P.; Huntington, Caleb; Dawson, David.

In: Biochemical Medicine and Metabolic Biology, Vol. 47, No. 1, 02.1992, p. 97-102.

Research output: Contribution to journal › Article › peer-review

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title = "A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice",

abstract = "We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.",

author = "Ann Sweet and Erickson, {Robert P.} and Caleb Huntington and David Dawson",

note = "Funding Information: This work was supported by Grant ZOll from the Cystic Fibrosis Foundation. We thank Mrs. Linda Yalkowsky, Ms. Debbie Bohlender, and Ms. Annette Spurr for secretarial support.",

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AU - Dawson, David

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A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Abstract

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