A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet; Robert P. Erickson; Caleb Huntington; David Dawson

doi:10.1016/0885-4505(92)90011-M

A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet, Robert P. Erickson, Caleb Huntington, David Dawson

Physiology & Pharmacology

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4 Scopus citations

Abstract

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl^- secretion in the DBA 2J than in the C57BL 6J strain. Their F₁ showed significantly higher levels of Cl^- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F₁ values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.

Original language	English (US)
Pages (from-to)	97-102
Number of pages	6
Journal	Biochemical Medicine and Metabolic Biology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0885-4505(92)90011-M
State	Published - Feb 1992

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ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry

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Sweet, A., Erickson, R. P., Huntington, C., & Dawson, D. (1992). A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. Biochemical Medicine and Metabolic Biology, 47(1), 97-102. https://doi.org/10.1016/0885-4505(92)90011-M

A potential animal model for studying CF heterozygote advantage : Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. / Sweet, Ann; Erickson, Robert P.; Huntington, Caleb; Dawson, David.

In: Biochemical Medicine and Metabolic Biology, Vol. 47, No. 1, 02.1992, p. 97-102.

Research output: Contribution to journal › Article

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10.1016/0885-4505(92)90011-M