A potential animal model for studying CF heterozygote advantage

Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet, Robert P. Erickson, Caleb Huntington, David Dawson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalBiochemical Medicine and Metabolic Biology
Volume47
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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Serous Membrane
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Inbred Strains Mice
Theophylline
Heterozygote
Oncogenes
Chlorides
Mucous Membrane
Animals
Animal Models
Alleles
Chromosomes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

A potential animal model for studying CF heterozygote advantage : Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. / Sweet, Ann; Erickson, Robert P.; Huntington, Caleb; Dawson, David.

In: Biochemical Medicine and Metabolic Biology, Vol. 47, No. 1, 1992, p. 97-102.

Research output: Contribution to journalArticle

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