A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Ann Sweet, Robert P. Erickson, Caleb Huntington, David Dawson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalBiochemical Medicine and Metabolic Biology
Volume47
Issue number1
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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