A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors

Dimitry S. Davydow, Ruth Kohen, Catherine L. Hough, Julia Helen Tracy, Douglas Zatzick, Wayne J. Katon

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Purpose: To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization. Materials and Methods: We extracted DNA for genotyping from saliva samples of 93 ICU patients enrolled in a prospective cohort investigation. Follow-up interviews conducted 3 and 12-months post-ICU included assessment of PTSD symptoms with the PTSD Checklist-Civilian Version and depressive symptoms with the Patient Health Questionnaire-9. Results: Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (β = 10.8, 95% confidence interval [95% CI], 17.7 to 3.9; P = .002) and depressive symptoms (β = 3.7, 95% CI, 6.7 to 0.7; P = .02). Carrying a CRHR1 rs1876831 C allele was associated with significantly more post-ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: β = 6.9, 95% CI, 1.2-12.6; P = .02; C/C homozygotes: β = 5.8; 95% CI: 0.2-11.3; P = .04). These associations remained significant after adjustment for age, race, illness severity, and in-ICU steroid exposure. Conclusions: Despite a small sample size, our findings suggest a potential role for genetic variants of CRHBP and CRHR1 in the development of post-ICU psychiatric morbidity.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of Critical Care
Volume29
Issue number1
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • Corticotrophin-releasing hormone binding protein
  • Corticotrophin-releasing hormone receptor-type 1
  • Critical care
  • Depression
  • Posttraumatic stress disorder

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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