A phase I study of liposomal doxorubicin (Doxil) with topotecan

Christopher W. Ryan, Gini F. Fleming, Linda Janisch, Mark J. Ratain

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    New therapies are needed for patients with advanced ovarian cancer who relapse after initial treatment with platinum and/or paclitaxel-based regimens. This study sought to determine the toxicities of combined liposomal doxorubicin (Doxil) and topotecan, and to determine a regimen for future phase II testing in ovarian cancer. Nine patients with advanced malignancies were treated with topotecan 1.0 mg/m2/day × 5 days followed by liposomal doxorubicin at a starting dose of 30 mg/m2 on day 5. Cycles were repeated every 28 days. A total of 13 cycles of therapy were administered. Grade IV neutropenia and grade IV thrombocytopenia developed in both of the two patients treated at the first dose level. Subsequent patients received only 20 mg/m2 liposomal doxorubicin. At that dose level, three patients experienced dose-limiting toxicity (one grade IV neutropenia, two grade IV neutropenia and thrombocytopenia). No responses were observed. These data indicate that the described regimen of liposomal doxorubicin and topotecan is not feasible because of excessive hematologic toxicity. Escalation to doses of liposomal doxorubicin or topotecan that have previously demonstrated antitumor activity was not possible. Future strategies to minimize such toxicity may include limiting eligibility to patients with minimal prior therapy, reducing the number of days of topotecan administration, or use of oral topotecan.

    Original languageEnglish (US)
    Pages (from-to)297-300
    Number of pages4
    JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
    Volume23
    Issue number3
    DOIs
    StatePublished - Dec 1 2000

    Keywords

    • Clinical trials
    • Doxorubicin
    • Ovarian neoplasms
    • Phase I
    • Topotecan

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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