A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice

Navid Mohammad Mirzaei, Zuzana Tatarova, Wenrui Hao, Navid Changizi, Alireza Asadpoure, Ioannis K. Zervantonakis, Yu Hu, Young Hwan Chang, Leili Shahriyari

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The evolution of breast tumors greatly depends on the interaction network among different cell types, including immune cells and cancer cells in the tumor. This study takes advantage of newly collected rich spatio-temporal mouse data to develop a data-driven mathematical model of breast tumors that considers cells’ location and key interactions in the tumor. The results show that cancer cells have a minor presence in the area with the most overall immune cells, and the number of activated immune cells in the tumor is depleted over time when there is no influx of immune cells. Interestingly, in the case of the influx of immune cells, the highest concentrations of both T cells and cancer cells are in the boundary of the tumor, as we use the Robin boundary condition to model the influx of immune cells. In other words, the influx of immune cells causes a dominant outward advection for cancer cells. We also investigate the effect of cells’ diffusion and immune cells’ influx rates in the dynamics of cells in the tumor micro-environment. Sensitivity analyses indicate that cancer cells and adipocytes’ diffusion rates are the most sensitive parameters, followed by influx and diffusion rates of cytotoxic T cells, implying that targeting them is a possible treatment strategy for breast cancer.

Original languageEnglish (US)
Article number807
JournalJournal of Personalized Medicine
Volume12
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • MMTV-PyMT mouse model
  • breast cancer
  • finite element method
  • immune cell influx
  • partial differential equation
  • sensitivity analysis
  • tumor microenvironment

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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