A novel method for the assessment of the accuracy of computing laminar flow stroke volumes using a real-time 3D ultrasound system

In vitro studies

Xiaokui Li, Muhammad Ashraf, Karl Thiele, Aarti Hejmadi Bhat, Ronald Sakaguchi, John C. Mitchell, Julie A. Brie, Monica Young, Rima S. Bader, James Pemberton, David Sahn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aims: Laminar flow stroke volume (SV) quantification in the ascending aorta or pulmonary artery can provide a measure for determining cardiac output (CO). Comparing flows across different valves can also compute shunt volumes and regurgitant fractions. Quantification methods for 3D color Doppler laminar flow volumes have been developed using reconstructive 3D, but these are cumbersome and time-consuming both in acquisition and measurement. Our study evaluated newly developed color Doppler mapping with real-time live 3D echo to test velocity, spatial and temporal resolution for computing SV. Methods and results: Five rubber tubes (diameters 1.9, 1.7 cm), a freshly dissected porcine aorta (Ao) and a pulmonary artery (PA) (both 2-3 cm diameter) were connected to a pulsatile pump in a water bath. Different SV, from 10 to 80 ml/beat, were studied at pump rates of 40-60 bpm in this phantom model with flow quantified by timed collection. The Nyquist limit was set between 43 and 100 cm/s and frame rate ranged from 14 to 23/s. ECG triggered 3D color Doppler volumes were acquired with a 2-4 MHz probe. The digital scan line data from the 3D volumes, with retained velocity assignments, was exported and analyzed offline by MatLab custom software. Close correlations were found between 3D calculated SV and reference data for all tubes (r = 0.98, y = 1.14x - 1.69, SEE = 2.82 ml/beat, p <0.0001). Both Ao and PA flows were also highly correlated with the reference measurements (PA: r = 0.98, SEE = 3.17 ml/beat; Ao: r = 0.99, SEE = 3.20 ml/beat). Conclusions: Real-time 3D color Doppler method could provide an efficient, accurate and reliable method for clinical evaluation and quantification of flow volumes in patients.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalEuropean Journal of Echocardiography
Volume6
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Stroke Volume
Pulmonary Artery
Aorta
Color
Rubber
Baths
Cardiac Output
Electrocardiography
Swine
Software
In Vitro Techniques
Water

Keywords

  • Color Doppler
  • Laminar flow
  • Live 3D
  • Stroke volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A novel method for the assessment of the accuracy of computing laminar flow stroke volumes using a real-time 3D ultrasound system : In vitro studies. / Li, Xiaokui; Ashraf, Muhammad; Thiele, Karl; Bhat, Aarti Hejmadi; Sakaguchi, Ronald; Mitchell, John C.; Brie, Julie A.; Young, Monica; Bader, Rima S.; Pemberton, James; Sahn, David.

In: European Journal of Echocardiography, Vol. 6, No. 6, 12.2005, p. 396-404.

Research output: Contribution to journalArticle

Li, Xiaokui ; Ashraf, Muhammad ; Thiele, Karl ; Bhat, Aarti Hejmadi ; Sakaguchi, Ronald ; Mitchell, John C. ; Brie, Julie A. ; Young, Monica ; Bader, Rima S. ; Pemberton, James ; Sahn, David. / A novel method for the assessment of the accuracy of computing laminar flow stroke volumes using a real-time 3D ultrasound system : In vitro studies. In: European Journal of Echocardiography. 2005 ; Vol. 6, No. 6. pp. 396-404.
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abstract = "Aims: Laminar flow stroke volume (SV) quantification in the ascending aorta or pulmonary artery can provide a measure for determining cardiac output (CO). Comparing flows across different valves can also compute shunt volumes and regurgitant fractions. Quantification methods for 3D color Doppler laminar flow volumes have been developed using reconstructive 3D, but these are cumbersome and time-consuming both in acquisition and measurement. Our study evaluated newly developed color Doppler mapping with real-time live 3D echo to test velocity, spatial and temporal resolution for computing SV. Methods and results: Five rubber tubes (diameters 1.9, 1.7 cm), a freshly dissected porcine aorta (Ao) and a pulmonary artery (PA) (both 2-3 cm diameter) were connected to a pulsatile pump in a water bath. Different SV, from 10 to 80 ml/beat, were studied at pump rates of 40-60 bpm in this phantom model with flow quantified by timed collection. The Nyquist limit was set between 43 and 100 cm/s and frame rate ranged from 14 to 23/s. ECG triggered 3D color Doppler volumes were acquired with a 2-4 MHz probe. The digital scan line data from the 3D volumes, with retained velocity assignments, was exported and analyzed offline by MatLab custom software. Close correlations were found between 3D calculated SV and reference data for all tubes (r = 0.98, y = 1.14x - 1.69, SEE = 2.82 ml/beat, p <0.0001). Both Ao and PA flows were also highly correlated with the reference measurements (PA: r = 0.98, SEE = 3.17 ml/beat; Ao: r = 0.99, SEE = 3.20 ml/beat). Conclusions: Real-time 3D color Doppler method could provide an efficient, accurate and reliable method for clinical evaluation and quantification of flow volumes in patients.",
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author = "Xiaokui Li and Muhammad Ashraf and Karl Thiele and Bhat, {Aarti Hejmadi} and Ronald Sakaguchi and Mitchell, {John C.} and Brie, {Julie A.} and Monica Young and Bader, {Rima S.} and James Pemberton and David Sahn",
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T1 - A novel method for the assessment of the accuracy of computing laminar flow stroke volumes using a real-time 3D ultrasound system

T2 - In vitro studies

AU - Li, Xiaokui

AU - Ashraf, Muhammad

AU - Thiele, Karl

AU - Bhat, Aarti Hejmadi

AU - Sakaguchi, Ronald

AU - Mitchell, John C.

AU - Brie, Julie A.

AU - Young, Monica

AU - Bader, Rima S.

AU - Pemberton, James

AU - Sahn, David

PY - 2005/12

Y1 - 2005/12

N2 - Aims: Laminar flow stroke volume (SV) quantification in the ascending aorta or pulmonary artery can provide a measure for determining cardiac output (CO). Comparing flows across different valves can also compute shunt volumes and regurgitant fractions. Quantification methods for 3D color Doppler laminar flow volumes have been developed using reconstructive 3D, but these are cumbersome and time-consuming both in acquisition and measurement. Our study evaluated newly developed color Doppler mapping with real-time live 3D echo to test velocity, spatial and temporal resolution for computing SV. Methods and results: Five rubber tubes (diameters 1.9, 1.7 cm), a freshly dissected porcine aorta (Ao) and a pulmonary artery (PA) (both 2-3 cm diameter) were connected to a pulsatile pump in a water bath. Different SV, from 10 to 80 ml/beat, were studied at pump rates of 40-60 bpm in this phantom model with flow quantified by timed collection. The Nyquist limit was set between 43 and 100 cm/s and frame rate ranged from 14 to 23/s. ECG triggered 3D color Doppler volumes were acquired with a 2-4 MHz probe. The digital scan line data from the 3D volumes, with retained velocity assignments, was exported and analyzed offline by MatLab custom software. Close correlations were found between 3D calculated SV and reference data for all tubes (r = 0.98, y = 1.14x - 1.69, SEE = 2.82 ml/beat, p <0.0001). Both Ao and PA flows were also highly correlated with the reference measurements (PA: r = 0.98, SEE = 3.17 ml/beat; Ao: r = 0.99, SEE = 3.20 ml/beat). Conclusions: Real-time 3D color Doppler method could provide an efficient, accurate and reliable method for clinical evaluation and quantification of flow volumes in patients.

AB - Aims: Laminar flow stroke volume (SV) quantification in the ascending aorta or pulmonary artery can provide a measure for determining cardiac output (CO). Comparing flows across different valves can also compute shunt volumes and regurgitant fractions. Quantification methods for 3D color Doppler laminar flow volumes have been developed using reconstructive 3D, but these are cumbersome and time-consuming both in acquisition and measurement. Our study evaluated newly developed color Doppler mapping with real-time live 3D echo to test velocity, spatial and temporal resolution for computing SV. Methods and results: Five rubber tubes (diameters 1.9, 1.7 cm), a freshly dissected porcine aorta (Ao) and a pulmonary artery (PA) (both 2-3 cm diameter) were connected to a pulsatile pump in a water bath. Different SV, from 10 to 80 ml/beat, were studied at pump rates of 40-60 bpm in this phantom model with flow quantified by timed collection. The Nyquist limit was set between 43 and 100 cm/s and frame rate ranged from 14 to 23/s. ECG triggered 3D color Doppler volumes were acquired with a 2-4 MHz probe. The digital scan line data from the 3D volumes, with retained velocity assignments, was exported and analyzed offline by MatLab custom software. Close correlations were found between 3D calculated SV and reference data for all tubes (r = 0.98, y = 1.14x - 1.69, SEE = 2.82 ml/beat, p <0.0001). Both Ao and PA flows were also highly correlated with the reference measurements (PA: r = 0.98, SEE = 3.17 ml/beat; Ao: r = 0.99, SEE = 3.20 ml/beat). Conclusions: Real-time 3D color Doppler method could provide an efficient, accurate and reliable method for clinical evaluation and quantification of flow volumes in patients.

KW - Color Doppler

KW - Laminar flow

KW - Live 3D

KW - Stroke volume

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