A novel family of mitochondrial plasmids associated with longevity mutants of Podospora anserina.

M. S. Turker, J. M. Domenico, D. J. Cummings

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Abstract

We have identified a novel family of plasmids, each containing very short monomeric units, in Podospora anserina longevity mutants. These plasmids, termed small mitochondrial DNAs (sMt-DNAs), are derived from a highly ordered 368-base pair region of the mitochondrial genome. A total of five direct repeat sequences and seven significant regions of dyad symmetry (i.e. palindromes) were found within a 434-base pair mitochondrial sequence, which includes this 368-base pair region. Mitochondrial DNA rearrangements accompany the formation of these small plasmids indicating their derivation from a plastic region of the mitochondrial genome. A possible relationship between the direct repeat sequences, the palindromic regions, and the excision process is discussed.

Original languageEnglish (US)
Pages (from-to)2250-2255
Number of pages6
JournalJournal of Biological Chemistry
Volume262
Issue number5
StatePublished - Feb 15 1987

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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