A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila

Peter J. Clyne, Coral G. Warr, Marc Freeman, Derek Lessing, Junhyong Kim, John R. Carlson

Research output: Contribution to journalArticle

742 Citations (Scopus)

Abstract

Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. We have developed a novel search algorithm, used it to search the Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. Different members of the family initiate expression at different times during antennal development. Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalNeuron
Volume22
Issue number2
StatePublished - 1999
Externally publishedYes

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Odorant Receptors
Olfactory Receptor Neurons
Drosophila
Insects
POU Domain Factors
Multigene Family
Genes
Organizations
Databases
Odorants

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Clyne, P. J., Warr, C. G., Freeman, M., Lessing, D., Kim, J., & Carlson, J. R. (1999). A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila. Neuron, 22(2), 327-338.

A novel family of divergent seven-transmembrane proteins : Candidate odorant receptors in Drosophila. / Clyne, Peter J.; Warr, Coral G.; Freeman, Marc; Lessing, Derek; Kim, Junhyong; Carlson, John R.

In: Neuron, Vol. 22, No. 2, 1999, p. 327-338.

Research output: Contribution to journalArticle

Clyne, PJ, Warr, CG, Freeman, M, Lessing, D, Kim, J & Carlson, JR 1999, 'A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila', Neuron, vol. 22, no. 2, pp. 327-338.
Clyne, Peter J. ; Warr, Coral G. ; Freeman, Marc ; Lessing, Derek ; Kim, Junhyong ; Carlson, John R. / A novel family of divergent seven-transmembrane proteins : Candidate odorant receptors in Drosophila. In: Neuron. 1999 ; Vol. 22, No. 2. pp. 327-338.
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