A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map

Lei Ren, Junan Zhang, Danthai Thongphiew, Devon J. Godfrey, Q. Jackie Wu, Su Min Zhou, Fang Fang Yin

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new projection data. Patients' previous cone-beam CT (CBCT) or planning CT data are used as the prior information, and the new patient volume to be reconstructed is considered as a deformation of the prior patient volume. The deformation field is solved by minimizing bending energy and maintaining new projection data fidelity using a nonlinear conjugate gradient method. The new patient DTS volume is then obtained by deforming the prior patient CBCT or CT volume according to the solution to the deformation field. This method is novel because it is the first method to combine deformable registration with limited angle image reconstruction. The method was tested in 2D cases using simulated projections of a Shepp-Logan phantom, liver, and head-and-neck patient data. The accuracy of the reconstruction was evaluated by comparing both organ volume and pixel value differences between DTS and CBCT images. In the Shepp-Logan phantom study, the reconstructed pixel signal-to-noise ratio (PSNR) for the 60°DTS image reached 34.3 dB. In the liver patient study, the relative error of the liver volume reconstructed using 60°projections was 3.4%. The reconstructed PSNR for the 60°DTS image reached 23.5 dB. In the head-and-neck patient study, the new method using 60°projections was able to reconstruct the 8.1°rotation of the bony structure with 0.0°error. The reconstructed PSNR for the 60°DTS image reached 24.2 dB. In summary, the new reconstruction method can optimally estimate the volumetric information in DTS images using 60°projections. Preliminary validation of the algorithm showed that it is both technically and clinically feasible for image guidance in radiation therapy.

Original languageEnglish (US)
Pages (from-to)3110-3115
Number of pages6
JournalMedical Physics
Volume35
Issue number7
DOIs
StatePublished - 2008

Keywords

  • Cone-beam CT
  • Deformable registration
  • Digital tomosynthesis
  • Image guided radiation therapy
  • Image reconstruction
  • Prior information

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map'. Together they form a unique fingerprint.

  • Cite this

    Ren, L., Zhang, J., Thongphiew, D., Godfrey, D. J., Jackie Wu, Q., Zhou, S. M., & Yin, F. F. (2008). A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map. Medical Physics, 35(7), 3110-3115. https://doi.org/10.1118/1.2940725