A novel device for left atrial appendage exclusion

Keiji Kamohara, Kiyotaka Fukamachi, Yoshio Ootaki, Masatoshi Akiyama, Firas Zahr, Michael W. Kopcak, Raymond Dessoffy, Zoran B. Popović, Masao Daimon, Delos M. Cosgrove, A. Marc Gillinov

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Objective: The left atrial appendage is a frequent source of thromboemboli in patients with atrial fibrillation. Exclusion or excision of the left atrial appendage may reduce the risk of stroke in patients with atrial fibrillation. We evaluated the ability of a novel device to exclude the left atrial appendage during early and intermediate follow-up periods in a canine model. Methods: Eight mongrel dogs (mean weight 29.1 ± 4.0 kg) were used in this study. The occlusion device, constructed from 2 stainless steel strips covered with a knit braided polyester fabric, was implanted at the base of the left atrial appendage through a left thoracotomy on a beating heart. Dogs were evaluated at 7 days (n = 2), 30 days (n = 2), and 90 days (n = 4) by epicardial echocardiography, left atrial angiography, histologic inspection, and gross pathology. Results: Device implantation was performed without complications in all animals. Complete exclusion of the left atrial appendage from the circulation was confirmed acutely and chronically by echocardiographic and angiographic evaluations. There was no device migration or damage to adjacent structures. Conclusion: This novel device enables rapid, reliable, and safe exclusion of the left atrial appendage. The device provides a new therapeutic option for reducing the risk of stroke in patients with atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)1639-1644
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume130
Issue number6
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Kamohara, K., Fukamachi, K., Ootaki, Y., Akiyama, M., Zahr, F., Kopcak, M. W., Dessoffy, R., Popović, Z. B., Daimon, M., Cosgrove, D. M., & Marc Gillinov, A. (2005). A novel device for left atrial appendage exclusion. Journal of Thoracic and Cardiovascular Surgery, 130(6), 1639-1644. https://doi.org/10.1016/j.jtcvs.2005.08.019