A novel chitosan dressing. Hemostatic efficacy in acute swine injury models: Splenic stripping compared to carotid laceration

S. J. McCarthy, J. Teach, L. Buckley, R. Q. Qian, L. Gibson, L. Lucchesi, T. Goodell, K. W. Gregory

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hemostatic efficacy of different forms of chitosan dressing in acute swine injury models were analyzed. Chitosan material forms consisted of powders, gels films and sponges were initially tested in a swine spleen laceration model where 30 second applications with digital pressure were used, followed by a 2 minutes period of observation for bleeding. The best performing chitosan form were compared against Gelfoam™+thrombin in an anti-coagulated swine spleen capsular stripping and carotid laceration model. It was observed that in the laceration model, chitosan as a powder, film and gel had no better efficacy than the negative control, whereas the sponge form showed equivalent performance to Gelfoam™+thrombin.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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    McCarthy, S. J., Teach, J., Buckley, L., Qian, R. Q., Gibson, L., Lucchesi, L., Goodell, T., & Gregory, K. W. (2004). A novel chitosan dressing. Hemostatic efficacy in acute swine injury models: Splenic stripping compared to carotid laceration. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).