@article{417a152fd7de44e6b555ac5ea7a7f97c,
title = "A Non-Randomized Trial Investigating the Impact of Brown Rice Consumption on Gut Microbiota, Attention, and Short-Term Working Memory in Thai School-Aged Children",
abstract = "While dietary fiber has been shown to influence the composition of gut microbiota and cognitive function in adults, much less is known about the fiber-microbiome-cognition association in children. We profiled gut microbiota using quantitative PCR (qPCR) and evaluated cognitive function using the Corsi block-tapping test (CBT) and the psychomotor vigilance test (PVT) before, during, and after the dietary intervention of 127 school-aged children in northern Thailand. While we found that Sinlek rice (SLR) consumption did not significantly alter the abundance of gut microbiota or the cognitive performance of school-aged children, we did find age to be associated with variations in both the gut microbiota profiles and cognitive outcomes. Gammaproteobacteria was significantly lower in the control and SLR groups during the middle time points of both phases (Weeks 4 and 61), and its abundance was associated with age. Cognitive performance using CBT and PVT were also found to be age-sensitive, as older children outperformed younger children on both of these cognitive assessments. Finally, a multiple factor analysis (MFA) revealed that age and cognitive performance best explain individual variation in this study. Collectively, these findings further describe the influence of host variables on the microbial profiles and cognitive outcomes of school-aged children consuming Sinlek rice in Thailand.",
keywords = "brown rice, cognitive performance, gut microbiota, school-aged children",
author = "Lucsame Gruneck and Marriott, {Lisa K.} and Eleni Gentekaki and Kongkiat Kespechara and Sharpton, {Thomas J.} and Justin Denny and Jackilen Shannon and Siam Popluechai",
note = "Funding Information: This collaborative study was funded by OHSU Global (Portland, OR, USA). The Let{\textquoteright}s Get Healthy! platform used for data collection was developed with the OHSU Clinical and Translational Research Institute (OCTRI; 1UL1TR002369) through funding from the National Institutes of Health (NIH), including Science Education Partnership Awards (R25OD01496, R25GM129840) and infrastructure developed by NIH grants R25RR020443-05S1, UL1RR024140-04S3, RR026008, 3P30CA-69553-13S9, and UL1TR002369. The Gut Microbiome research group was funded by Mae Fah Luang University. Funding Information: The authors would like to thank all participants who contributed fecal samples and demographic information. We would like to express our appreciation to Channarong Wanthanjai for his technical assistance. We appreciate Angie Setthavongsack for her assistance with cognitive analysis, whose effort was supported by the National Institutes of Health Common Fund and Office of Scientific Workforce Diversity under three linked awards RL5GM118963, TL4GM118965, and UL1GM118964, administered by the National Institute of General Medical Sciences. We thank Mae Fah Luang University for supporting the Gut Microbiome Research Group. Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = dec,
doi = "10.3390/nu14235176",
language = "English (US)",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "23",
}