A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir

Sunwen Chou, Camie L. Meichsner

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Abstract

A deletion mutation (codons 595 to 603) in the cytomegalovirus (CMV) UL97 gene was recently reported after sequence analysis of leukocyte DNA from a patient receiving ganciclovir. The corresponding viral phenotype was examined by transfer of this mutation to a laboratory CMV strain (strain Towne). The recombinant virus was resistant to ganciclovir (8.4-fold increase in the 50% inhibitory concentration), was sensitive to foscarnet, and replicated normally in cell culture.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number1
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Pharmacology (medical)

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