A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir

Sunwen Chou, Camie L. Meichsner

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A deletion mutation (codons 595 to 603) in the cytomegalovirus (CMV) UL97 gene was recently reported after sequence analysis of leukocyte DNA from a patient receiving ganciclovir. The corresponding viral phenotype was examined by transfer of this mutation to a laboratory CMV strain (strain Towne). The recombinant virus was resistant to ganciclovir (8.4-fold increase in the 50% inhibitory concentration), was sensitive to foscarnet, and replicated normally in cell culture.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number1
StatePublished - 2000

Fingerprint

Ganciclovir
Sequence Deletion
Cytomegalovirus
Codon
Phosphotransferases
Foscarnet
DNA Sequence Analysis
Genes
Inhibitory Concentration 50
Leukocytes
Cell Culture Techniques
Viruses
Phenotype
Mutation

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir. / Chou, Sunwen; Meichsner, Camie L.

In: Antimicrobial Agents and Chemotherapy, Vol. 44, No. 1, 2000, p. 183-185.

Research output: Contribution to journalArticle

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