A nicotinic cholinergic agonist (gts - 21) andeyeblink classical conditioning: Acquisition, retention, and relearning in older rabbits

Diana S. Woodruff-Pak, John T. Green, Catherine Coleman-Valencia, Jonathan T. Pak

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Previously we demonstrated that GTS-21, a nicotinic cholinergic agonist, ameliorated eyeblink classical conditioning deficits in older rabbits. The present experiment was undertaken to replicate and extend these results by examining the effects of GTS-21 on retention and relearning. Retired breeder rabbits received 15 daily injections of 0.5 mg/kg GTS 21 (n = 8) or sterile saline vehicle (n = 8) during acquisition training, and no further injections occurred. Acquisition of conditioned responses (CRs) was significantly better in GTS-21-treated rabbits. During the first tone-alone retention session in week 6 of the experiment, rabbits initially treated with GTS-21 produced significantly more CRs than vehicle-treated rabbits. There were no group differences in retention at the 13-week retest. Differences in relearning were in the predicted direction but did not attain statistical significance. Results indicate that treatment with GTS-21 ameliorates learning beyond the period when the drug is actually ad ministered.

Original languageEnglish (US)
Pages (from-to)323-336
Number of pages14
JournalExperimental aging research
Volume26
Issue number4
DOIs
StatePublished - Oct 1 2000

ASJC Scopus subject areas

  • Aging
  • Arts and Humanities (miscellaneous)
  • Psychology(all)
  • Geriatrics and Gerontology

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