TY - JOUR
T1 - A nicotinic cholinergic agonist (gts - 21) andeyeblink classical conditioning
T2 - Acquisition, retention, and relearning in older rabbits
AU - Woodruff-Pak, Diana S.
AU - Green, John T.
AU - Coleman-Valencia, Catherine
AU - Pak, Jonathan T.
N1 - Funding Information:
The authors would like to thank Michelle H. Pak for her assistance with animal testing. As sta€at theAlbert Einstein Medical Center Animal Facility, Daniel P. Lyons and Isagani S. Santos were especially helpful and made these experiments possible. The research was supported by a grant from Taiho Pharmaceutical Co., Ltd., Tokyo, Japan.
PY - 2000/10/1
Y1 - 2000/10/1
N2 - Previously we demonstrated that GTS-21, a nicotinic cholinergic agonist, ameliorated eyeblink classical conditioning deficits in older rabbits. The present experiment was undertaken to replicate and extend these results by examining the effects of GTS-21 on retention and relearning. Retired breeder rabbits received 15 daily injections of 0.5 mg/kg GTS 21 (n = 8) or sterile saline vehicle (n = 8) during acquisition training, and no further injections occurred. Acquisition of conditioned responses (CRs) was significantly better in GTS-21-treated rabbits. During the first tone-alone retention session in week 6 of the experiment, rabbits initially treated with GTS-21 produced significantly more CRs than vehicle-treated rabbits. There were no group differences in retention at the 13-week retest. Differences in relearning were in the predicted direction but did not attain statistical significance. Results indicate that treatment with GTS-21 ameliorates learning beyond the period when the drug is actually ad ministered.
AB - Previously we demonstrated that GTS-21, a nicotinic cholinergic agonist, ameliorated eyeblink classical conditioning deficits in older rabbits. The present experiment was undertaken to replicate and extend these results by examining the effects of GTS-21 on retention and relearning. Retired breeder rabbits received 15 daily injections of 0.5 mg/kg GTS 21 (n = 8) or sterile saline vehicle (n = 8) during acquisition training, and no further injections occurred. Acquisition of conditioned responses (CRs) was significantly better in GTS-21-treated rabbits. During the first tone-alone retention session in week 6 of the experiment, rabbits initially treated with GTS-21 produced significantly more CRs than vehicle-treated rabbits. There were no group differences in retention at the 13-week retest. Differences in relearning were in the predicted direction but did not attain statistical significance. Results indicate that treatment with GTS-21 ameliorates learning beyond the period when the drug is actually ad ministered.
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U2 - 10.1080/036107300750015723
DO - 10.1080/036107300750015723
M3 - Article
C2 - 11091939
AN - SCOPUS:0033736632
SN - 0361-073X
VL - 26
SP - 323
EP - 336
JO - Experimental aging research
JF - Experimental aging research
IS - 4
ER -