A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism

Adrian Harvey, Meng Jun Hu, Manjula Gupta, Robert Butler, Jamie Mitchell, Eren Berber, Allan Siperstein, Mira Milas

    Research output: Contribution to journalArticle

    19 Scopus citations

    Abstract

    Objective: To refine the diagnostic criteria for primary hyperparathyroidism (1°HPT) to identify atypical patients, in whom serum calcium, parathyroid hormone (PTH), or both are within the "normal" range.Methods: Total serum calcium, intact PTH, and 25-hydroxyvitamin D [25(OH)D] levels were measured in patients with 1°HPT and healthy patient groups. Multivariate analysis of healthy patient data first identified factors that significantly affected PTH levels and defined a new PTH reference range with a mathematical model. That nomogram was then validated for prediction of atypical 1°HPT in patients with surgically confirmed disease.Results: On multivariate analysis, calcium (P = .0002), 25(OH)D (P<.0001), and age (P = .015) independently affected PTH. With these variables, we created a 4-dimensional nomogram that distinguished normal patients from those with hyperparathyroid states. Mathematically, this nomogram predicts 1°HPT when the measured serum PTH value is higher than PTH calculated by the following formula: PTH (pg/mL) = 120 - [6 × calcium (mg/dL)] - [0.52 × 25(OH)D (ng/mL)] + [0.26 × patient age (years)]. When applied to our surgical group of patients, this nomogram successfully identified 100% of patients (238 of 238) with classic 1°HPT, 84% (64 of 76) with normocalcemic 1°HPT, and 54% (20 of 37) with 1°HPT and normal PTH.Conclusion: This study uniquely defines a patient-specific upper limit of normal for PTH based on the readily available variables of serum calcium, 25(OH)D, and patient age. Our nomogram may allow for more rapid definitive diagnosis and treatment of 1°HPT in patients with atypical presentations.

    Original languageEnglish (US)
    Pages (from-to)124-131
    Number of pages8
    JournalEndocrine Practice
    Volume18
    Issue number2
    DOIs
    StatePublished - Mar 1 2012

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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    Harvey, A., Hu, M. J., Gupta, M., Butler, R., Mitchell, J., Berber, E., Siperstein, A., & Milas, M. (2012). A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism. Endocrine Practice, 18(2), 124-131. https://doi.org/10.4158/EP10389.OR