A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism

Adrian Harvey, MengJun Hu, Manjula Gupta, Robert Butler, Jamie Mitchell, Eren Berber, Allan Siperstein, Kresimira Milas

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To refine the diagnostic criteria for primary hyperparathyroidism (1°HPT) to identify atypical patients, in whom serum calcium, parathyroid hormone (PTH), or both are within the "normal" range.Methods: Total serum calcium, intact PTH, and 25-hydroxyvitamin D [25(OH)D] levels were measured in patients with 1°HPT and healthy patient groups. Multivariate analysis of healthy patient data first identified factors that significantly affected PTH levels and defined a new PTH reference range with a mathematical model. That nomogram was then validated for prediction of atypical 1°HPT in patients with surgically confirmed disease.Results: On multivariate analysis, calcium (P = .0002), 25(OH)D (P

Original languageEnglish (US)
Pages (from-to)124-131
Number of pages8
JournalEndocrine Practice
Volume18
Issue number2
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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Nomograms
Primary Hyperparathyroidism
Vitamin D
Parathyroid Hormone
Calcium
Reference Values
Multivariate Analysis
Serum
Theoretical Models

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Harvey, A., Hu, M., Gupta, M., Butler, R., Mitchell, J., Berber, E., ... Milas, K. (2012). A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism. Endocrine Practice, 18(2), 124-131. https://doi.org/10.4158/EP10389.OR

A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism. / Harvey, Adrian; Hu, MengJun; Gupta, Manjula; Butler, Robert; Mitchell, Jamie; Berber, Eren; Siperstein, Allan; Milas, Kresimira.

In: Endocrine Practice, Vol. 18, No. 2, 01.03.2012, p. 124-131.

Research output: Contribution to journalArticle

Harvey, A, Hu, M, Gupta, M, Butler, R, Mitchell, J, Berber, E, Siperstein, A & Milas, K 2012, 'A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism', Endocrine Practice, vol. 18, no. 2, pp. 124-131. https://doi.org/10.4158/EP10389.OR
Harvey, Adrian ; Hu, MengJun ; Gupta, Manjula ; Butler, Robert ; Mitchell, Jamie ; Berber, Eren ; Siperstein, Allan ; Milas, Kresimira. / A new, vitamin D-based, multidimensional nomogram for the diagnosis of primary hyperparathyroidism. In: Endocrine Practice. 2012 ; Vol. 18, No. 2. pp. 124-131.
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