Abstract
[18F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [ 18F]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%.
Original language | English (US) |
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Pages (from-to) | 923-927 |
Number of pages | 5 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 48 |
Issue number | 12 |
DOIs | |
State | Published - Oct 30 2005 |
Externally published | Yes |
Keywords
- Fluorine-18
- Hypoxia
- Misonidazole
- Positron emission tomography
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry