A new synthesis of the labeling precursor for [18F]- fluoromisonidazole

Tom C H Adamsen, John R. Grierson, Kenneth Krohn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

[18F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [ 18F]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%.

Original languageEnglish (US)
Pages (from-to)923-927
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
Issue number12
DOIs
StatePublished - Oct 30 2005
Externally publishedYes

Fingerprint

Labeling
Radiopharmaceuticals
Purification
Tumors
Imaging techniques
fluoromisonidazole
1,3-dibromo-2-propanol
Tumor Hypoxia

Keywords

  • Fluorine-18
  • Hypoxia
  • Misonidazole
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

A new synthesis of the labeling precursor for [18F]- fluoromisonidazole. / Adamsen, Tom C H; Grierson, John R.; Krohn, Kenneth.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 48, No. 12, 30.10.2005, p. 923-927.

Research output: Contribution to journalArticle

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