A new mouse tumor model system (RIF-1) for comparison of end-point studies

P. R. Twentyman, J. M. Brown, Joe Gray, A. J. Franko, M. A. Scoles, R. F. Kallman

Research output: Contribution to journalArticle

412 Citations (Scopus)

Abstract

A new tumor model system (RIF-1) was developed that is very suitable for studies in which clonogenic survival is compared with growth delay and control probability following various forms of treatment. The tumor was a radiation-induced sarcoma in the inbred female C3H/Km mouse. It had a low median tumor dose, had a satisfactory plating efficiency direct from in vivo to in vitro, was nonimmunogenic or minimally immunogenic, and metastasized only at a relatively advanced stage of growth. The cell line grew either as a monolayer on plastic dishes, as tumor spheroids in spinner culture, as lung nodules following injection of a single-cell suspension into the tail veins of syngeneic mice, or as a solid tumor. Both diploid and tetraploid clonogenic cells were found in monolayer cultures of the RIF-1 line.

Original languageEnglish (US)
Pages (from-to)595-604
Number of pages10
JournalJournal of the National Cancer Institute
Volume64
Issue number3
StatePublished - 1980
Externally publishedYes

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Neoplasms
Hindlimb Suspension
Tetraploidy
Inbred C3H Mouse
Growth
Diploidy
Sarcoma
Plastics
Veins
Radiation
Cell Line
Lung
Injections
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Twentyman, P. R., Brown, J. M., Gray, J., Franko, A. J., Scoles, M. A., & Kallman, R. F. (1980). A new mouse tumor model system (RIF-1) for comparison of end-point studies. Journal of the National Cancer Institute, 64(3), 595-604.

A new mouse tumor model system (RIF-1) for comparison of end-point studies. / Twentyman, P. R.; Brown, J. M.; Gray, Joe; Franko, A. J.; Scoles, M. A.; Kallman, R. F.

In: Journal of the National Cancer Institute, Vol. 64, No. 3, 1980, p. 595-604.

Research output: Contribution to journalArticle

Twentyman, PR, Brown, JM, Gray, J, Franko, AJ, Scoles, MA & Kallman, RF 1980, 'A new mouse tumor model system (RIF-1) for comparison of end-point studies', Journal of the National Cancer Institute, vol. 64, no. 3, pp. 595-604.
Twentyman, P. R. ; Brown, J. M. ; Gray, Joe ; Franko, A. J. ; Scoles, M. A. ; Kallman, R. F. / A new mouse tumor model system (RIF-1) for comparison of end-point studies. In: Journal of the National Cancer Institute. 1980 ; Vol. 64, No. 3. pp. 595-604.
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