A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors

Q. Zhang; S. J. Gould; T. M. Zabriskie

doi:10.1021/np970468o

A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors

Q. Zhang, S. J. Gould, T. M. Zabriskie

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The identification new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).

Original language	English (US)
Pages (from-to)	648-651
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	5
DOIs	https://doi.org/10.1021/np970468o
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np970468o

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abstract = "The identification new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).",

author = "Q. Zhang and Gould, {S. J.} and Zabriskie, {T. M.}",

year = "1998",

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AB - The identification new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).

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A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors

Abstract

ASJC Scopus subject areas

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