A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors

Q. Zhang, S. J. Gould, T. M. Zabriskie

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The identification new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number5
DOIs
StatePublished - Jun 18 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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