A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors

Q. Zhang, S. J. Gould, Mark Zabriskie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The identification new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Streptomyces griseochromogenes
Argininosuccinate Synthase
Enzyme inhibition
Antifungal Agents
enzyme inhibitors
cytosine
Cytosine
Biosynthetic Pathways
Streptomyces
Enzyme Inhibitors
Glycosides
Metabolites
Fermentation
Arginine
glycosides
blasticidin S
enzyme inhibition
acids
Enzymes
arginine

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors. / Zhang, Q.; Gould, S. J.; Zabriskie, Mark.

In: Journal of Natural Products, Vol. 61, No. 5, 1998, p. 648-651.

Research output: Contribution to journalArticle

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