A new class of reversible cell cycle inhibitors

Benjamin Hoffman, Hartmut M. Hanauske‐Abel, Alan Flint, Marc Lalande

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The effects of three compounds on the cell cycle of HL‐60 promyeloid leukemia cells has been examined. Ciclopirox olamine, an antifungal agent, and the compound Hoechst 768159 reversibly block the cell cycle at a point occurring roughly 1 h before the arrest mediated by aphidicolin, an inhibitor of DNA polymerase á activity, which acts in early S phase. Similar results are also obtained with the compound mimosine, a plant amino acid. Based on these data, it is concluded that all three agents inhibit cell cycle traverse at or very near the G1/S phase boundary and identify a previously undefined reversible cell cycle arrest point.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalCytometry
Volume12
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Cell Cycle
ciclopirox
S Phase
Mimosine
Aphidicolin
Nucleic Acid Synthesis Inhibitors
Antifungal Agents
G1 Phase
Cell Cycle Checkpoints
Leukemia
Amino Acids

Keywords

  • ciclopirox olamine
  • Flow cytometry
  • G1 phase block
  • mimosine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biophysics
  • Hematology
  • Endocrinology
  • Cell Biology

Cite this

Hoffman, B., Hanauske‐Abel, H. M., Flint, A., & Lalande, M. (1991). A new class of reversible cell cycle inhibitors. Cytometry, 12(1), 26-32. https://doi.org/10.1002/cyto.990120105

A new class of reversible cell cycle inhibitors. / Hoffman, Benjamin; Hanauske‐Abel, Hartmut M.; Flint, Alan; Lalande, Marc.

In: Cytometry, Vol. 12, No. 1, 1991, p. 26-32.

Research output: Contribution to journalArticle

Hoffman, B, Hanauske‐Abel, HM, Flint, A & Lalande, M 1991, 'A new class of reversible cell cycle inhibitors', Cytometry, vol. 12, no. 1, pp. 26-32. https://doi.org/10.1002/cyto.990120105
Hoffman, Benjamin ; Hanauske‐Abel, Hartmut M. ; Flint, Alan ; Lalande, Marc. / A new class of reversible cell cycle inhibitors. In: Cytometry. 1991 ; Vol. 12, No. 1. pp. 26-32.
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