A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

Erick A. Perez-Alday, Haibo Ni, Christopher Hamilton, Annabel Li-Pershing, Bernard Jaar, Jose M. Monroy-Trujillo, Michelle Estrella, Rulan Parekh, Henggui Zhang, Larisa Tereshchenko

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.

    Original languageEnglish (US)
    Title of host publicationComputing in Cardiology Conference, CinC 2018
    PublisherIEEE Computer Society
    ISBN (Electronic)9781728109589
    DOIs
    StatePublished - Sep 2018
    Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
    Duration: Sep 23 2018Sep 26 2018

    Publication series

    NameComputing in Cardiology
    Volume2018-September
    ISSN (Print)2325-8861
    ISSN (Electronic)2325-887X

    Conference

    Conference45th Computing in Cardiology Conference, CinC 2018
    CountryNetherlands
    CityMaastricht
    Period9/23/189/26/18

    ASJC Scopus subject areas

    • Computer Science(all)
    • Cardiology and Cardiovascular Medicine

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  • Cite this

    Perez-Alday, E. A., Ni, H., Hamilton, C., Li-Pershing, A., Jaar, B., Monroy-Trujillo, J. M., Estrella, M., Parekh, R., Zhang, H., & Tereshchenko, L. (2018). A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity. In Computing in Cardiology Conference, CinC 2018 [8743829] (Computing in Cardiology; Vol. 2018-September). IEEE Computer Society. https://doi.org/10.22489/CinC.2018.161