A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

Erick A. Perez-Alday, Haibo Ni, Christopher Hamilton, Annabel Li-Pershing, Bernard Jaar, Jose M. Monroy-Trujillo, Michelle Estrella, Rulan Parekh, Henggui Zhang, Larisa Tereshchenko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology Conference, CinC 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781728109589
DOIs
StatePublished - Sep 2018
Externally publishedYes
Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
Duration: Sep 23 2018Sep 26 2018

Publication series

NameComputing in Cardiology
Volume2018-September
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference45th Computing in Cardiology Conference, CinC 2018
Country/TerritoryNetherlands
CityMaastricht
Period9/23/189/26/18

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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