A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

LINCS Consortium

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Factors that impact the reproducibility of experimental data are poorly understood. Five NIH-LINCS centers performed the same set of drug-response measurements and compared results. Technical and biological variables that impact precision and reproducibility and are also sensitive to biological context were the most problematic.

Original languageEnglish (US)
Pages (from-to)35-48.e5
JournalCell Systems
Volume9
Issue number1
DOIs
StatePublished - Jul 24 2019

Keywords

  • cancer drugs
  • cell line
  • dose response
  • high[HYPHEN]throughput
  • microscopy
  • oncology
  • pharmacology
  • reproducibility
  • screening

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Fingerprint Dive into the research topics of 'A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines'. Together they form a unique fingerprint.

Cite this