A mouse model of alcoholism

Huub Rijk, John Jr Crabbe, Henk Rigter

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time. Mice were injected daily with pyrazole, an inhibitor of alcohol dehydrogenase. The animals self-administered ethanol by inhaling vapour containing a relatively constant concentration of ethanol. Self-administration was voluntary: the mice could move to a chamber without ethanol vapour. During the first six days of each experiment, the animals were prompted to select the ethanol chamber by darkening that chamber. Most mice continued to self-administer ethanol without any prompting for at least 3 days; thereafter, preference for ethanol waned. Self-administration led to measurable levels of ethanol in blood and to the development of withdrawal when infusion of vapour was stopped.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalPhysiology and Behavior
Volume29
Issue number5
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Alcoholism
Ethanol
Self Administration
Alcohol Dehydrogenase
Inhalation
Alcohols
Pharmaceutical Preparations

Keywords

  • Alcohol dependence
  • Alcoholism
  • Animal model
  • Inhalation of ethanol
  • Self-administration of ethanol
  • Withdrawal

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

A mouse model of alcoholism. / Rijk, Huub; Crabbe, John Jr; Rigter, Henk.

In: Physiology and Behavior, Vol. 29, No. 5, 1982, p. 833-839.

Research output: Contribution to journalArticle

Rijk, Huub ; Crabbe, John Jr ; Rigter, Henk. / A mouse model of alcoholism. In: Physiology and Behavior. 1982 ; Vol. 29, No. 5. pp. 833-839.
@article{605c09801aa84514b47abe3e27fcf9b0,
title = "A mouse model of alcoholism",
abstract = "A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of {"}alcoholism{"} in a large number of animals within a short period of time. Mice were injected daily with pyrazole, an inhibitor of alcohol dehydrogenase. The animals self-administered ethanol by inhaling vapour containing a relatively constant concentration of ethanol. Self-administration was voluntary: the mice could move to a chamber without ethanol vapour. During the first six days of each experiment, the animals were prompted to select the ethanol chamber by darkening that chamber. Most mice continued to self-administer ethanol without any prompting for at least 3 days; thereafter, preference for ethanol waned. Self-administration led to measurable levels of ethanol in blood and to the development of withdrawal when infusion of vapour was stopped.",
keywords = "Alcohol dependence, Alcoholism, Animal model, Inhalation of ethanol, Self-administration of ethanol, Withdrawal",
author = "Huub Rijk and Crabbe, {John Jr} and Henk Rigter",
year = "1982",
doi = "10.1016/0031-9384(82)90333-X",
language = "English (US)",
volume = "29",
pages = "833--839",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - A mouse model of alcoholism

AU - Rijk, Huub

AU - Crabbe, John Jr

AU - Rigter, Henk

PY - 1982

Y1 - 1982

N2 - A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time. Mice were injected daily with pyrazole, an inhibitor of alcohol dehydrogenase. The animals self-administered ethanol by inhaling vapour containing a relatively constant concentration of ethanol. Self-administration was voluntary: the mice could move to a chamber without ethanol vapour. During the first six days of each experiment, the animals were prompted to select the ethanol chamber by darkening that chamber. Most mice continued to self-administer ethanol without any prompting for at least 3 days; thereafter, preference for ethanol waned. Self-administration led to measurable levels of ethanol in blood and to the development of withdrawal when infusion of vapour was stopped.

AB - A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time. Mice were injected daily with pyrazole, an inhibitor of alcohol dehydrogenase. The animals self-administered ethanol by inhaling vapour containing a relatively constant concentration of ethanol. Self-administration was voluntary: the mice could move to a chamber without ethanol vapour. During the first six days of each experiment, the animals were prompted to select the ethanol chamber by darkening that chamber. Most mice continued to self-administer ethanol without any prompting for at least 3 days; thereafter, preference for ethanol waned. Self-administration led to measurable levels of ethanol in blood and to the development of withdrawal when infusion of vapour was stopped.

KW - Alcohol dependence

KW - Alcoholism

KW - Animal model

KW - Inhalation of ethanol

KW - Self-administration of ethanol

KW - Withdrawal

UR - http://www.scopus.com/inward/record.url?scp=0020365234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020365234&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(82)90333-X

DO - 10.1016/0031-9384(82)90333-X

M3 - Article

VL - 29

SP - 833

EP - 839

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -