A mitochondrial perspective on cell death

Paolo Bernardi, Valeria Petronilli, Fabio Di Lisa, Michael Forte

Research output: Contribution to journalReview article

361 Scopus citations

Abstract

The role of mitochondria as crucial participants in cell death programs is well established, yet the mechanisms responsible for the release of mitochondrial activators and the role of BCL2 family proteins in this process remain controversial. Here, we point out the limitations of current approaches used to monitor the physiological responses of mitochondria during cell death, the implications arising from modern views of mitochondrial structure, and briefly assess two proposed mechanisms for the release of mitochondrial proteins during apoptosis.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalTrends in Biochemical Sciences
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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