A microsatellite-based index map of human chromosome 11

M. Litt, P. Kramer, X. Y. Hauge, J. L. Weber, Z. Wang, P. J. Wilkie, M. S. Holt, S. Mishra, H. Donis-Keller, L. Warnich, A. E. Retief, C. Jones, J. Weissenbach

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We have constructed a continuous index map of 25 microsatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygosities of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105:1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

Original languageEnglish (US)
Pages (from-to)909-913
Number of pages5
JournalHuman Molecular Genetics
Volume2
Issue number7
StatePublished - Jul 1993

Fingerprint

Microsatellites
Chromosomes, Human, Pair 11
Human Chromosomes
Chromosomes
Microsatellite Repeats
Chromosome
Hybrid Cells
Cytogenetics
In Situ Hybridization
Polymerase Chain Reaction
Locus
Genes
Odds
Human
Inversion
High Resolution
Adjacent
Cover
Gene
Cell

ASJC Scopus subject areas

  • Genetics
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Genetics(clinical)

Cite this

Litt, M., Kramer, P., Hauge, X. Y., Weber, J. L., Wang, Z., Wilkie, P. J., ... Weissenbach, J. (1993). A microsatellite-based index map of human chromosome 11. Human Molecular Genetics, 2(7), 909-913.

A microsatellite-based index map of human chromosome 11. / Litt, M.; Kramer, P.; Hauge, X. Y.; Weber, J. L.; Wang, Z.; Wilkie, P. J.; Holt, M. S.; Mishra, S.; Donis-Keller, H.; Warnich, L.; Retief, A. E.; Jones, C.; Weissenbach, J.

In: Human Molecular Genetics, Vol. 2, No. 7, 07.1993, p. 909-913.

Research output: Contribution to journalArticle

Litt, M, Kramer, P, Hauge, XY, Weber, JL, Wang, Z, Wilkie, PJ, Holt, MS, Mishra, S, Donis-Keller, H, Warnich, L, Retief, AE, Jones, C & Weissenbach, J 1993, 'A microsatellite-based index map of human chromosome 11', Human Molecular Genetics, vol. 2, no. 7, pp. 909-913.
Litt M, Kramer P, Hauge XY, Weber JL, Wang Z, Wilkie PJ et al. A microsatellite-based index map of human chromosome 11. Human Molecular Genetics. 1993 Jul;2(7):909-913.
Litt, M. ; Kramer, P. ; Hauge, X. Y. ; Weber, J. L. ; Wang, Z. ; Wilkie, P. J. ; Holt, M. S. ; Mishra, S. ; Donis-Keller, H. ; Warnich, L. ; Retief, A. E. ; Jones, C. ; Weissenbach, J. / A microsatellite-based index map of human chromosome 11. In: Human Molecular Genetics. 1993 ; Vol. 2, No. 7. pp. 909-913.
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AU - Holt, M. S.

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AU - Donis-Keller, H.

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