A microsatellite-based index map of human chromosome 11

M. Litt, P. Kramer, X. Y. Hauge, J. L. Weber, Z. Wang, P. J. Wilkle, M. S. Holt, S. Mishra, H. Donis-keller, L. Warnich, A. E. Retief, C. Jones, J. Welssenbach

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Abstract

We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

Original languageEnglish (US)
Pages (from-to)909-913
Number of pages5
JournalHuman molecular genetics
Volume2
Issue number7
DOIs
StatePublished - Jul 1 1993

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Litt, M., Kramer, P., Hauge, X. Y., Weber, J. L., Wang, Z., Wilkle, P. J., Holt, M. S., Mishra, S., Donis-keller, H., Warnich, L., Retief, A. E., Jones, C., & Welssenbach, J. (1993). A microsatellite-based index map of human chromosome 11. Human molecular genetics, 2(7), 909-913. https://doi.org/10.1093/hmg/2.7.909