A Methodology for Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma

Stephen A. Schwaner, Alison M. Kight, Robert N. Perry, Marta Pazos, Hongli Yang, Elaine Johnson, John Morrison, Claude F. Burgoyne, C. Ross Ethier

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glaucoma is the leading cause of irreversible blindness and involves the death of retinal ganglion cells (RGCs). Although biomechanics likely contributes to axonal injury within the optic nerve head (ONH), leading to RGC death, the pathways by which this occurs are not well understood. While rat models of glaucoma are well-suited for mechanistic studies, the anatomy of the rat ONH is different from the human, and the resulting differences in biomechanics have not been characterized. The aim of this study is to describe a methodology for building individual-specific finite element (FE) models of rat ONHs. This method was used to build three rat ONH FE models and compute the biomechanical environment within these ONHs. Initial results show that rat ONH strains are larger and more asymmetric than those seen in human ONH modeling studies. This method provides a framework for building additional models of normotensive and glaucomatous rat ONHs. Comparing model strain patterns with patterns of cellular response seen in studies using rat glaucoma models will help us to learn more about the link between biomechanics and glaucomatous cell death, which in turn may drive the development of novel therapies for glaucoma.

Original languageEnglish (US)
Article number084501
JournalJournal of Biomechanical Engineering
Volume140
Issue number8
DOIs
StatePublished - Aug 1 2018

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Biomechanics
Optic Disk
Biomechanical Phenomena
Glaucoma
Rats
Optics
Retinal Ganglion Cells
Cell death
Cell Death
Blindness
Anatomy
Wounds and Injuries

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

A Methodology for Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma. / Schwaner, Stephen A.; Kight, Alison M.; Perry, Robert N.; Pazos, Marta; Yang, Hongli; Johnson, Elaine; Morrison, John; Burgoyne, Claude F.; Ross Ethier, C.

In: Journal of Biomechanical Engineering, Vol. 140, No. 8, 084501, 01.08.2018.

Research output: Contribution to journalArticle

Schwaner, Stephen A. ; Kight, Alison M. ; Perry, Robert N. ; Pazos, Marta ; Yang, Hongli ; Johnson, Elaine ; Morrison, John ; Burgoyne, Claude F. ; Ross Ethier, C. / A Methodology for Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma. In: Journal of Biomechanical Engineering. 2018 ; Vol. 140, No. 8.
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