A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms

K. J. Burchel, G. Schmer

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A rapid fluorometric assay technique has been utilized to assess the degree of fibrinolytic inhibition in 20 patients with ruptured intracranial aneurysms treated with epsilon-aminocaproic acid (EACA). This method quantitates the available plasminogen activity (APA) of plasma, and has proven to be a reliable means of monitoring antifibrinolytic therapy. Determination of the plasma APA also permits correlation of the level of fibrinolytic activity with putative complications of EACA therapy. Normal control plasma APA was 3.1 ± 0.7 CTA units/ml, but in patients with subarachnoid hemorrhage (SAH), pretreatment, fibrinolytic activity was supranormal at 3.78 ± 0.88 CTA units/ml. During continuous intravenous administration of EACA (1.5 mg/hr) in patients with SAH, the plasma fibrinolytic activity was decreased to 0.9 ± 0.31 CTA units/ml. A case is described which exemplifies the use of this assay. In addition, an approach to monitoring antifibrinolytic therapy using the plasma APA is proposed.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalJournal of neurosurgery
Volume54
Issue number1
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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