A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

M. Heo; R. L. Leibel; K. R. Fontaine; B. B. Boyer; W. K. Chung; M. Koulu; M. K. Karvonen; U. Pesonen; A. Rissanen; M. Laakso; M. I.J. Uusitupa; Y. Chagnon; C. Bouchard; P. A. Donohoue; T. L. Burns; A. R. Shuldiner; K. Silver; R. E. Andersen; O. Pedersen; S. Echwald; T. I.A. Sørensen; P. Behn; M. A. Permutt; K. B. Jacobs; R. C. Elston; D. J. Hoffman; E. Gropp; D. B. Allison

doi:10.1038/sj.ijo.0801990

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

M. Heo, R. L. Leibel, K. R. Fontaine, B. B. Boyer, W. K. Chung, M. Koulu, M. K. Karvonen, U. Pesonen, A. Rissanen, M. Laakso, M. I.J. Uusitupa, Y. Chagnon, C. Bouchard, P. A. Donohoue, T. L. Burns, A. R. Shuldiner, K. Silver, R. E. Andersen, O. Pedersen, S. EchwaldT. I.A. Sørensen, P. Behn, M. A. Permutt, K. B. Jacobs, R. C. Elston, D. J. Hoffman, E. Gropp, D. B. Allison

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109 Scopus citations

Abstract

METHOD: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K1O9R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m²) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested effects of individual alleles, joint effects of alleles at multiple loci, epistatic effects among alleles at different loci, effect modification by age, sex, diabetes and ethnicity, and pleiotropic genotype effects on BMI and WC. RESULTS: We found that none of the effects were significant at the 0.05 level. Heterogeneity tests showed that the variations of the non-significant effects are within the range of sampling variation. CONCLUSION: We conclude that, although certain genotypic effects could be population-specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or WC in the overall population.

Original language	English (US)
Pages (from-to)	640-646
Number of pages	7
Journal	International Journal of Obesity
Volume	26
Issue number	5
DOIs	https://doi.org/10.1038/sj.ijo.0801990
State	Published - 2002
Externally published	Yes

Keywords

Association
Body mass index
Leptin receptor polymorphism
Linkage
Meta-analysis
Waist circumference

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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10.1038/sj.ijo.0801990

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Heo, M., Leibel, R. L., Fontaine, K. R., Boyer, B. B., Chung, W. K., Koulu, M., Karvonen, M. K., Pesonen, U., Rissanen, A., Laakso, M., Uusitupa, M. I. J., Chagnon, Y., Bouchard, C., Donohoue, P. A., Burns, T. L., Shuldiner, A. R., Silver, K., Andersen, R. E., Pedersen, O., ... Allison, D. B. (2002). A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. International Journal of Obesity, 26(5), 640-646. https://doi.org/10.1038/sj.ijo.0801990

Heo, M, Leibel, RL, Fontaine, KR, Boyer, BB, Chung, WK, Koulu, M, Karvonen, MK, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, MIJ, Chagnon, Y, Bouchard, C, Donohoue, PA, Burns, TL, Shuldiner, AR, Silver, K, Andersen, RE, Pedersen, O, Echwald, S, Sørensen, TIA, Behn, P, Permutt, MA, Jacobs, KB, Elston, RC, Hoffman, DJ, Gropp, E & Allison, DB 2002, 'A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference', International Journal of Obesity, vol. 26, no. 5, pp. 640-646. https://doi.org/10.1038/sj.ijo.0801990

@article{7dd20da0e7b344baaab2532589f5ee21,

title = "A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference",

abstract = "METHOD: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K1O9R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m2) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested effects of individual alleles, joint effects of alleles at multiple loci, epistatic effects among alleles at different loci, effect modification by age, sex, diabetes and ethnicity, and pleiotropic genotype effects on BMI and WC. RESULTS: We found that none of the effects were significant at the 0.05 level. Heterogeneity tests showed that the variations of the non-significant effects are within the range of sampling variation. CONCLUSION: We conclude that, although certain genotypic effects could be population-specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or WC in the overall population.",

keywords = "Association, Body mass index, Leptin receptor polymorphism, Linkage, Meta-analysis, Waist circumference",

author = "M. Heo and Leibel, {R. L.} and Fontaine, {K. R.} and Boyer, {B. B.} and Chung, {W. K.} and M. Koulu and Karvonen, {M. K.} and U. Pesonen and A. Rissanen and M. Laakso and Uusitupa, {M. I.J.} and Y. Chagnon and C. Bouchard and Donohoue, {P. A.} and Burns, {T. L.} and Shuldiner, {A. R.} and K. Silver and Andersen, {R. E.} and O. Pedersen and S. Echwald and S{\o}rensen, {T. I.A.} and P. Behn and Permutt, {M. A.} and Jacobs, {K. B.} and Elston, {R. C.} and Hoffman, {D. J.} and E. Gropp and Allison, {D. B.}",

note = "Funding Information: This study was supported in part by the NIH grants R01DK51716, R01DK52431, R01ES09912, F33DK09919, P30DK26687, DK25295 and P41RR03655. We thank Drs Jose Fernandez and Gary Gadbury for their valuable input.",

year = "2002",

doi = "10.1038/sj.ijo.0801990",

language = "English (US)",

volume = "26",

pages = "640--646",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "5",

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TY - JOUR

T1 - A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

AU - Heo, M.

AU - Leibel, R. L.

AU - Fontaine, K. R.

AU - Boyer, B. B.

AU - Chung, W. K.

AU - Koulu, M.

AU - Karvonen, M. K.

AU - Pesonen, U.

AU - Rissanen, A.

AU - Laakso, M.

AU - Uusitupa, M. I.J.

AU - Chagnon, Y.

AU - Bouchard, C.

AU - Donohoue, P. A.

AU - Burns, T. L.

AU - Shuldiner, A. R.

AU - Silver, K.

AU - Andersen, R. E.

AU - Pedersen, O.

AU - Echwald, S.

AU - Sørensen, T. I.A.

AU - Behn, P.

AU - Permutt, M. A.

AU - Jacobs, K. B.

AU - Elston, R. C.

AU - Hoffman, D. J.

AU - Gropp, E.

AU - Allison, D. B.

N1 - Funding Information: This study was supported in part by the NIH grants R01DK51716, R01DK52431, R01ES09912, F33DK09919, P30DK26687, DK25295 and P41RR03655. We thank Drs Jose Fernandez and Gary Gadbury for their valuable input.

PY - 2002

Y1 - 2002

N2 - METHOD: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K1O9R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m2) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested effects of individual alleles, joint effects of alleles at multiple loci, epistatic effects among alleles at different loci, effect modification by age, sex, diabetes and ethnicity, and pleiotropic genotype effects on BMI and WC. RESULTS: We found that none of the effects were significant at the 0.05 level. Heterogeneity tests showed that the variations of the non-significant effects are within the range of sampling variation. CONCLUSION: We conclude that, although certain genotypic effects could be population-specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or WC in the overall population.

AB - METHOD: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K1O9R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m2) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested effects of individual alleles, joint effects of alleles at multiple loci, epistatic effects among alleles at different loci, effect modification by age, sex, diabetes and ethnicity, and pleiotropic genotype effects on BMI and WC. RESULTS: We found that none of the effects were significant at the 0.05 level. Heterogeneity tests showed that the variations of the non-significant effects are within the range of sampling variation. CONCLUSION: We conclude that, although certain genotypic effects could be population-specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or WC in the overall population.

KW - Association

KW - Body mass index

KW - Leptin receptor polymorphism

KW - Linkage

KW - Meta-analysis

KW - Waist circumference

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U2 - 10.1038/sj.ijo.0801990

DO - 10.1038/sj.ijo.0801990

M3 - Article

C2 - 12032747

AN - SCOPUS:18344396039

SN - 0307-0565

VL - 26

SP - 640

EP - 646

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 5

ER -

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

Abstract

Keywords

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